Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats

Lee, Kyeong-Soo; Kim, Hyun Pyo; Park, Hyun Jin; Yoon, Young Geol

doi:10.1007/s10068-020-00872-x

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…여 주에는 비타민 C, 사포닌, 알칼로이드, 글루코사이드 등의 유용 물질과 혈당 강하 기능이 있는 charantin이 높게 함유되어 있다 [7]. 이러한 성분들로 인하여 인슐린의 분비가 촉진되고 혈당을 낮추며 동맥경화와 고혈압 같은 성인병, 항균작용, 항산화작용, 항암작용, 항괴사작용, 당뇨합병증 예방 및 항당뇨 기능 등의 효능이 보고되고 있다 [6,8]. 특히, 여주추출물을 고지방식이로 유 도한 비만마우스 모델에 공급했을 때 체중 증가와 내장 지방의 축적 및 지방 세포 비대를 억제하고 혈중 지방대사 기능을 조 절하여 비만을 억제하는 항비만 활성을 지니고 있음이 확인되 었다 [9,10].…”

Section: 서 론unclassified

Anti-obesity effect of the combination of fermented extracts from Momordica charanatia and Withania somnifera in mice fed a high-fat diet

Choi

Park

Yoon

2022

JABC

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We investigated the serum cholesterol and visceral fat lowering effects of Momordica charanatia (MC) and Withania somnifera (WS) extracts in high-fat diet (HFD)-fed mice. Combination of fermented MC and WS extracts (FMCWS) as well as that of non-fermented extracts (MCWS) were orally administered to HFD-induced obese mice along with the HFD supplementation for 8 weeks. During the experiment, body weight, food intake, and levels of total cholesterol, triglyceride and HDL-cholesterol were analyzed. Body weight and the levels of total cholesterol and triglycerides were significantly increased in the HFD-fed mice compared with the normal control (NC) group. However, supplementation of the extracts showed a tendency to reduce body weight gain and suppressed the levels of total cholesterol and triglyceride with the increment of HDLcholesterol levels. Abdominal fat weight was significantly increased in the HFD group, and the size of adipocytes within the epididymal adipose tissue was markedly expanded compared with the NC group. However, in the FMCWS and MCWS groups, the abdominal fat weight was significantly reduced and the sizes of the adipocytes were noticeably diminished compared with those of the HFD-fed mice. Moreover, the deposition of giant vesicular fat cells observed in the liver tissue of the HFD group was prominently reduced in these groups. These results indicate that the combination of extracts from MC and WS tends to have potent synergic effects in reducing body weight gain as well as significantly lowering the visceral fat and the serum lipid levels, and thus improving anti-obesity efficacy in HFD-induced obese mice.

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Section: 서 론unclassified

Anti-obesity effect of the combination of fermented extracts from Momordica charanatia and Withania somnifera in mice fed a high-fat diet

Choi

Park

Yoon

2022

JABC

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“…Recently, alternative studies have been conducted to develop new substances that boost testosterone. These substances promote testosterone secretion by regulating the body’s production of testosterone by using naturally occurring materials, such as plants, fungi, and insects [ 17 – 20 ]. In addition, further information on the bioavailability and efficacy of the rich bioactive compounds in natural products is needed, due to the growing public interest in the development of "functional foods" [ 21 , 22 ] and the increasing trend for health-consciousness among consumers [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of elderberry (Sambucus nigra L.) extract and extract-derived monosaccharide-amino acid on H2O2-induced decrease in testosterone-deficiency syndrome in a TM3 Leydig cell

Lee,

Kim,

Kong

et al. 2024

PLoS ONE

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With aging, men develop testosterone-deficiency syndrome (TDS). The development is closely associated with age-related mitochondrial dysfunction of Leydig cell and oxidative stress-induced reactive oxygen species (ROS). Testosterone-replacement therapy (TRT) is used to improve the symptoms of TDS. However, due to its various side effects, research on functional ingredients derived from natural products that do not have side effects is urgently needed. In this study, using the mitochondrial dysfunction TM3 (mouse Leydig) cells, in which testosterone biosynthesis is reduced by H2O2, we evaluated the effects of elderberry extract and monosaccharide-amino acid (fructose–leucine; FL) on mRNA and protein levels related to steroidogenesis-related enzymes steroidogenic acute regulatory protein (StAR), cytochrome P450 11A1(CYP11A1, cytochrome P450 17A1(CYP17A1), cytochrome P450 19A1(CYP19A1, aromatase), 3β-hydroxysteroid dehydrogenase (3β-HSD), and 17β-hydroxysteroid dehydrogenase(17β-HSD). We analyzed elderberry extract and extract-derived FL for changes in ROS scavenging activity and testosterone secretion. Elderberry extract and FL significantly reduced H2O2-induced intracellular ROS levels, improved testosterone secretion, and increased the mRNA and protein expression levels of steroidogenesis-related enzymes (StAR, 3b-HSD, 17b-HSD, CYP11A1, CYp17A1). However, the conversion of testosterone to estradiol was inhibited by elderberry extract and extract-derived FL, which reduced the mRNA and protein expression of CYP19A1. In conclusion, elderberry extract and FL are predicted to have value as novel functional ingredients that may contribute to the prevention of TDS by ameliorating reduced steroidogenesis.

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Combination of berberine and silibinin improves lipid metabolism and anti-obesity efficacy in high-fat diet-fed obese mice

Lee

Choi

Yoon

2021

JABC

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In this study, we investigated whether the combined administration of berberine (BBR) and silibinin (SBN) was effective in improving hyperlipidemia and anti-obesity efficacy using a high-fat diet (HFD)-fed obese mouse model. HFDinduced obese mice were supplemented with the BBR and SBN combination (BBR-SBN) along with the HFD administration for 8 weeks. During the experiment, body weight, food intake, and levels of total cholesterol, triglyceride and high-density lipoprotein (HDL)-cholesterol were analyzed. Consumption of HFD in the mice caused rapid increases in body weight and the levels of total cholesterol and triglycerides compared to the normal control (NC) group. However, supplementation of BBR-SBN in these obese mice significantly reduced body weight gain and suppressed the levels of total cholesterol and triglyceride with the increment of HDL cholesterol level. In the HFD-fed group, abdominal fat weight was significantly increased and the adipocytes within the epididymal adipose tissue were found to have expanded sizes compared to the NC group. However, in the BBR-SBN group, the sizes of the adipocytes were comparable to those of the NC group and abdominal fat weight was significantly reduced. Moreover, the deposition of giant vesicular fat cells in liver tissues seen in the HFD-fed group was considerably reduced in the BBR-SBN group. These results suggest that the BBR-SBN combination tends to have synergic potential as an anti-obesity agent by significantly reducing body weight gain as well as lowering serum lipid levels and thus improving anti-obesity efficacy in HFDinduced obese mice.

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Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats

Cited by 4 publications

References 38 publications

Anti-obesity effect of the combination of fermented extracts from Momordica charanatia and Withania somnifera in mice fed a high-fat diet

Anti-obesity effect of the combination of fermented extracts from Momordica charanatia and Withania somnifera in mice fed a high-fat diet

Ameliorative effects of elderberry (Sambucus nigra L.) extract and extract-derived monosaccharide-amino acid on H2O2-induced decrease in testosterone-deficiency syndrome in a TM3 Leydig cell

Combination of berberine and silibinin improves lipid metabolism and anti-obesity efficacy in high-fat diet-fed obese mice

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