Improvement of the anti-Candida activity of itraconazole in the zebrafish infection model by its coordination to silver(I)

Stevanović, Nevena Lj.; Glišić, Biljana Đ.; Vojnović, Sandra; Wadepohl, Hubert; Andrejević, Tina P.; Đurić, Sonja; Savić, Nada D.; Nikodinovic-Runic, Jasmina; Djuran, Miloš I.; Pavić, Aleksandar

doi:10.1016/j.molstruc.2021.130006

Cited by 12 publications

(13 citation statements)

References 71 publications

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“…In line with these studies, Pavic et al showed that the survival of C. albicans-infected embryos is in strong correlation with the level of fungus filamentation, and that by blocking hyphal formation with Ag(I) complexes it is possible to rescue embryos from the lethal infection. 76 In this study, we found that C. albicans filamentation was completely supressed in the fungus-infected hindbrain already at ½ × MIC dose of ReNN6Py and ReNN6BzIm, as well as at 1 × MIC dose of ReNN3Py. In comparison to the control (untreated) group, much shorter and less dense hyphae occurred upon treatment with ½ × MIC dose of ReNN6Py or the antifungal drug itraconazole (Fig.…”

Section: Re(i) Tricarbonyl Complexes Successfully Inhibit C Albicans Filamentation and Infection Progresssupporting

confidence: 47%

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Sovari

Radakovic

Roch

et al. 2021

Preprint

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Antimicrobial resistance (AMR) is a major emerging threat to public health, causing serious issues in the successful prevention and treatment of persistent diseases. While the problem escalates, lack of financial incentive has lead major pharmaceutical companies to interrupt their antibiotic drug discovery programs. The World Health Organisation (WHO) has called for novel solutions outside the traditional development pathway, with emphasis on new classes of active compounds with nonclassical mechanisms of action. Metal complexes are an untapped source of antibiotic potential owing to unique modes of action and a wider range of three-dimensional geometries as compared to purely organic compounds. In this study, we present the antimicrobial and antifungal efficacy of a family of rhenium tricarbonyl diimine complexes with varying ligands, charge and lipophilicity. Our study allowed the identification of potent and non-toxic complexes active in vivo against S. aureus infections at MIC doses as low as 300 ng/mL, as well as against C. albicans-MRSA mixed co-infection. The compounds are capable of suppressing the C. albicans morphogenetic yeast-to-hyphal transition, eradicating fungal-S. aureus co-infection, while showing no sign of cardio-, hepato-, hematotoxiciy or teratogenicity.The following ALERTS were generated. Each ALERT has the format test-name_ALERT_alert-type_alert-level. Click on the hyperlinks for more details of the test.

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Section: Re(i) Tricarbonyl Complexes Successfully Inhibit C Albicans Filamentation and Infection Progresssupporting

confidence: 47%

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Sovari

Radakovic

Roch

et al. 2021

Preprint

Self Cite

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Section: Re(i) Tricarbonyl Complexes Successfully Inhibit C Albicans Filamentation and Infection Progressmentioning

confidence: 59%

“…This model provides a unique opportunity to dissect host and pathogen interaction, as well as the effect of applied therapies on the yeast-to-hyphae transition and eradication of the fungal infection. [75][76][77] The therapeutic efficacy of ReNN3Py, ReNN6Py and ReNN6BzIm was appraised by assessing the survival rate of C. albicans-infected embryos and the potential inhibitory effect of the compounds on fungal filamentation.…”

Section: Re(i) Tricarbonyl Complexes Successfully Inhibit C Albicans Filamentation and Infection Progressmentioning

confidence: 99%

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Sovari

Radakovic

Roch

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

In this study, we present the antimicrobial and antifungal efficacy of a family of rhenium tricarbonyl diimine complexes with varying ligands, charge and lipophilicity. Our study allowed the identification of potent and non-toxic complexes active in vivo against antimicrobial infections at MIC doses as low as 330 ng/mL and C. albicans-MRSA mixed co-infection. The compounds are capable of suppressing the C. albicans morphogenetic yeast-to-hyphal transition, eradicating fungal-S. aureus co-infection, while showing no sign of cardio-, hepato-, hematotoxiciy or teratogenicity.

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“…and Clavispora spp. Itraconazole is an azole antifungal that is effective against a broad spectrum of clinically relevant fungi and is used as a first-line agent for the prevention and treatment of invasive superficial infections [ 46 ]. Undoubtedly, Candida albicans is among the most widespread pathogenic yeasts.…”

Section: Resultsmentioning

confidence: 99%

Smoothie Drinks: Possible Source of Resistant and Biofilm-Forming Microorganisms

Šilha

Syrová

Syrová³

et al. 2022

Foods

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Smoothie drinks are currently very popular drinks sold especially in fast food establishments. However, smoothies are a significant source of microorganisms. The aim of this study was to evaluate the microbiological quality of smoothies purchased in Eastern Bohemia. A higher prevalence of mesophilic aerobic bacteria (5.4–7.2 log CFU/mL), yeast (4.4–5.9 log CFU/mL) and coliform bacteria (3.1–6.0 log CFU/mL) was observed in vegetable smoothies, in which even the occurrence of enterococci (1.6–3.3 log CFU/mL) was observed. However, the occurrence of S. aureus, Salmonella spp. and Listeria spp. was not observed in any samples. Nevertheless, antimicrobial resistance was observed in 71.8% of the isolated strains. The highest level of resistance was found in isolates from smoothie drinks with predominantly vegetable contents (green smoothie drinks). Considerable resistance was observed in Gram-negative rods, especially to amoxicillin (82.2%) and amoxicillin with clavulanic acid (55.6%). Among enterococci, only one vancomycin-resistant strain was detected. The vast majority of isolated strains were able to form biofilms at a significant level, which increases the clinical importance of these microorganisms. The highest biofilm production was found in Pseudomonas aeruginosa, Kocuria kristinae and Klebsiella pneumoniae. Overall, significant biofilm production was also noted among isolates of Candida spp.

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Improvement of the anti-Candida activity of itraconazole in the zebrafish infection model by its coordination to silver(I)

Cited by 12 publications

References 71 publications

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Combatting AMR: a molecular approach to the discovery of potent and non-toxic rhenium complexes active against C. albicans-MRSA co-infection

Smoothie Drinks: Possible Source of Resistant and Biofilm-Forming Microorganisms

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