Improvement of the cellular quality of cryopreserved bovine blastocysts accompanied by enhancement of the ATP-binding cassette sub-family B member 1 expression

Mori, Masayuki; Kasa, Shojiro; Isozaki, Y.; Kamori, Tsugumitsu; Yamaguchi, Shoichiro; Ueda, Shuji; Kuwano, T.; Eguchi, Mika; Isayama, Keishiro; Nishimura, Shigeyuki; Shoji, Tetsuo; Yamauchi, Nobuhiko; Hattori, Masa Aki

doi:10.1016/j.reprotox.2012.11.002

Cited by 11 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Expression of these two genes was significantly increased after IRW treatment. As a member of ABC (ATP‐binding cassette) proteins, ABCB‐1's primary role is to provide a first line of defense at the cellular level by inhibiting entry of potentially harmful compounds into the cell and excreting toxic metabolites out of the cell . Overexpression of ABCB‐1 also controls the production of leukocyte and thus can control the inflammatory response .…”

Section: Discussionmentioning

confidence: 99%

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

Majumder

Liang

Chen

et al. 2015

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeEgg ovotransferrin‐derived angiotensin converting enzyme (ACE) inhibitory peptide IRW was previously shown to reduce blood pressure in spontaneously hypertensive rats through reduced vascular inflammation and increased nitric oxide‐mediated vasorelaxation. The main objective of the present study was to investigate the molecular mechanism of this peptide through transcriptome analysis by RNAseq technique.Methods and resultsTotal RNA was extracted from kidney and mesenteric arteries; the RNAseq libraries (from untreated and IRW‐treated groups) were constructed and subjected to sequence using HiSeq 2000 system (Illumina) system. A total of 12 764 and 13 352 genes were detected in kidney and mesenteric arteries, respectively. The differentially expressed (DE) genes between untreated and IRW‐treated groups were identified and the functional analysis through ingenuity pathway analysis revealed a greater role of DE genes identified from mesenteric arteries than that of kidney in modulating various cardiovascular functions. Subsequent qPCR analysis further confirmed that IRW significantly increased the expression of ACE‐2, ABCB‐1, IRF‐8, and CDH‐1 while significantly decreased the expression ICAM‐1 and VCAM‐1 in mesenteric arteries.ConclusionOur research showed for the first time that ACE inhibitory peptide IRW could contribute to its antihypertensive activity through increased ACE2 and decreased proinflammatory genes expression.

show abstract

Section: Discussionmentioning

confidence: 99%

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

Majumder

Liang

Chen

et al. 2015

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Moreover, bovine embryos treated with forskolin (an activator of adenylyl cyclase) plus rifampicin (an antibiotic) exhibited a 1.8-fold increase in ABCB1 mRNA levels. After cryopreservation, blastocysts treated with forskolin and rifampicin, which expressed high levels of ABCB1, demonstrated significantly increased viability (16.8%), blastocyst hatching (15.4%) and cell proliferation rates compared with control blastocysts (Mori et al, 2013), suggesting that embryonic developmental competence improves with increased expression of ABCB1 during segmentation.…”

Section: Abca1 (Tgd)mentioning

confidence: 98%

ATP-binding cassette transporters in reproduction: a new frontier

Bloise

Ortiga-Carvalho

Reis

et al. 2015

Hum. Reprod. Update

169

View full text Add to dashboard Cite

The ABC transporters have various roles across multiple reproductive tissues. Knowledge of efflux direction, tissue distribution, substrate specificity and regulation of the ABC transporters in the placenta and other reproductive tissues is rapidly expanding. This will allow better understanding of the disposition of specific substrates within reproductive tissues, and facilitate development of novel treatments for reproductive disorders as well as improved approaches to protecting the developing fetus.

show abstract

Biochemical alterations in the oocyte in support of early embryonic development

Martin

Bromfield

Aitken

et al. 2016

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Notwithstanding the enormous reproductive potential encapsulated within a mature mammalian oocyte, these cells present only a limited window for fertilization before defaulting to an apoptotic cascade known as post-ovulatory oocyte aging. The only cell with the capacity to rescue this potential is the fertilizing spermatozoon. Indeed, the union of these cells sets in train a remarkable series of events that endows the oocyte with the capacity to divide and differentiate into the trillions of cells that comprise a new individual. Traditional paradigms hold that, beyond the initial stimulation of fluctuating calcium (Ca) required for oocyte activation, the fertilizing spermatozoon plays limited additional roles in the early embryo. While this model has now been drawn into question in view of the recent discovery that spermatozoa deliver developmentally important classes of small noncoding RNAs and other epigenetic modulators to oocytes during fertilization, it is nevertheless apparent that the primary responsibility for oocyte activation rests with a modest store of maternally derived proteins and mRNA accumulated during oogenesis. It is, therefore, not surprising that widespread post-translational modifications, in particular phosphorylation, hold a central role in endowing these proteins with sufficient functional diversity to initiate embryonic development. Indeed, proteins targeted for such modifications have been linked to oocyte activation, recruitment of maternal mRNAs, DNA repair and resumption of the cell cycle. This review, therefore, seeks to explore the intimate relationship between Ca release and the suite of molecular modifications that sweep through the oocyte to ensure the successful union of the parental germlines and ensure embryogenic fidelity.

show abstract

Improvement of the cellular quality of cryopreserved bovine blastocysts accompanied by enhancement of the ATP-binding cassette sub-family B member 1 expression

Cited by 11 publications

References 36 publications

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

ATP-binding cassette transporters in reproduction: a new frontier

Biochemical alterations in the oocyte in support of early embryonic development

Contact Info

Product

Resources

About