1976
DOI: 10.1177/000331977602700306
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Improvement of the Flow Properties of Blood: a New Therapeutical Approach in Occlusive Arterial Disease

Abstract: The general pathophysiological basis in occlusive arterial disease is the reduced flow rate of blood in the microcirculation. Blood flow in the ischemic tissue can be increased by improving the flow properties of blood. The fibrinogen concentration of blood and the deformability of red cells are two main factors determining the flow properties of blood. Ancrod, a fibrinogen-lowering substance, improves the flow properties of blood by decreasing the viscosity of blood and plasma and by desaggregation of erythro… Show more

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Cited by 115 publications
(19 citation statements)
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“…The distention of microaneurysm^ walls causes a relative insufficiency of their infiltration barrier and results in the formation of edema and hard exudates in the retina (Davis 1968 limited ischaemic infarction in the inner retinal layers (Kohner et al 1967;Davis 1968). Moreover, the impaired RBCD, which signifies an increase in blood viscosity (Dintenfass 1976,Ehrly 1976), can cause a decrease of blood flow in the microcirculation and finally tissue hypoxia with lactic acidosis and consequent microvascular lesion (Ashton 1963). These changes lead to a further increase in viscosity, i.e.…”
Section: Groupsmentioning
confidence: 99%
“…The distention of microaneurysm^ walls causes a relative insufficiency of their infiltration barrier and results in the formation of edema and hard exudates in the retina (Davis 1968 limited ischaemic infarction in the inner retinal layers (Kohner et al 1967;Davis 1968). Moreover, the impaired RBCD, which signifies an increase in blood viscosity (Dintenfass 1976,Ehrly 1976), can cause a decrease of blood flow in the microcirculation and finally tissue hypoxia with lactic acidosis and consequent microvascular lesion (Ashton 1963). These changes lead to a further increase in viscosity, i.e.…”
Section: Groupsmentioning
confidence: 99%
“…They concluded that the major mechanism by which PXF raised CBF was rheological rather than a vasodilating effect [ 13]. Several researchers have reached similar conclusions [4,7,23].…”
Section: Discussionmentioning
confidence: 84%
“…The effects of ancrod on blood coagulation, fibrinogen and viscosity were described in the 1970s [2, 6, 7, 8]. Ancrod rapidly lyses fibrinogen, producing soluble fibrin clots which are cleared by the reticuloendothelial system.…”
Section: Setting the Stagementioning
confidence: 99%
“…In 1974, ancrod treatment to reduce fibrinogen was suggested as a treatment for peripheral arterial disease [6]. Improvement of blood flow properties was noted [7], and studies in 1977 and 1978 used ancrod for the treatment of ischemic extremities due to obliterating arterial disease [2]. All studies were based on the premise that reduced fibrinogen levels would reduce viscosity, and improve blood flow in the microcirculation.…”
Section: Setting the Stagementioning
confidence: 99%