Improvement of the Off-Resonance Saturation, an MRI sequence for positive contrast with SPM particles: Theoretical and experimental study

Delangre, Sébastien; Vuong, Quoc Lam; Po, Chrystelle; Gallez, Bernard; Gossuin, Yves

doi:10.1016/j.jmr.2016.02.002

Cited by 5 publications

(6 citation statements)

References 47 publications

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“…We adapted an ORS method 39 , 46 to quantify the mineral‐iron pool in the postmortem brain tissue of 5 patients affected by neurological diseases associated with increased brain iron. This method can aid the interpretation of

and QSM maps, especially when these are confounded by reconstruction artifacts or the co‐presence of iron and myelin.…”

Section: Discussionmentioning

confidence: 99%

“…We added a frequency offset

(δ υ)

to account for resonance frequency shifts. Because N = 6 saturation pulses were used to enhance the saturation, 46 the final expression for the contrast becomes:

C (normalΔ ν_{0}) = N M_{italiccontrol} ϕ (normalΔ ν_{0}) + o f f .

…”

Section: Methodsmentioning

confidence: 99%

“…We added a frequency offset ( ) to account for resonance frequency shifts. Because N = 6 saturation pulses were used to enhance the saturation, 46 the final expression for the contrast becomes: M control is weighted by the proton density, relaxation times, and flip angle. 47 The offset (off) term in the equation above was introduced to account for residual MT effects and imperfect saturation.…”

Section: Mri Data Processingmentioning

confidence: 99%

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Off‐resonance saturation as an MRI method to quantify mineral‐ iron in the post‐mortem brain

Bossoni

Hegeman-Kleinn

Duinen

et al. 2021

Magnetic Resonance in Med

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Purpose:To employ an off-resonance saturation method to measure the mineraliron pool in the postmortem brain, which is an endogenous contrast agent that can give information on cellular iron status.Methods: An off-resonance saturation acquisition protocol was implemented on a 7 Tesla preclinical scanner, and the contrast maps were fitted to an established analytical model. The method was validated by correlation and Bland-Altman analysis on a ferritin-containing phantom. Mineral-iron maps were obtained from postmortem tissue of patients with neurological diseases characterized by brain iron accumulation, that is, Alzheimer disease, Huntington disease, and aceruloplasminemia, and validated with histology. Transverse relaxation rate and magnetic susceptibility values were used for comparison. Results: In postmortem tissue, the mineral-iron contrast colocalizes with histological iron staining in all the cases. Iron concentrations obtained via the off-resonance saturation method are in agreement with literature. Conclusions:Off-resonance saturation is an effective way to detect iron in gray matter structures and partially mitigate for the presence of myelin. If a reference region with little iron is available in the tissue, the method can produce quantitative iron maps. This method is applicable in the study of diseases characterized by brain iron accumulation and can complement existing iron-sensitive parametric methods.

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and QSM maps, especially when these are confounded by reconstruction artifacts or the co‐presence of iron and myelin.…”

Section: Discussionmentioning

confidence: 99%

“…We added a frequency offset

(δ υ)

to account for resonance frequency shifts. Because N = 6 saturation pulses were used to enhance the saturation, 46 the final expression for the contrast becomes:

C (normalΔ ν_{0}) = N M_{italiccontrol} ϕ (normalΔ ν_{0}) + o f f .

…”

Section: Methodsmentioning

confidence: 99%

Section: Mri Data Processingmentioning

confidence: 99%

See 1 more Smart Citation

Off‐resonance saturation as an MRI method to quantify mineral‐ iron in the post‐mortem brain

Bossoni

Hegeman-Kleinn

Duinen

et al. 2021

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…In conclusion, we adapted an ORS method 47,40 to quantify the ferritin-bound iron pool in the post-mortem brain tissue of three patients affected by neurological diseases associated with increased brain iron. This method can aid the interpretation of R 2 * and QSM maps, especially when these are confounded by reconstruction artifacts or the co-presence of iron and myelin.…”

Section: Discussionmentioning

confidence: 99%

“…A frequency offset (δυ) was added to account for resonance frequency shifts. Since N=6 saturation pulses were used to enhance the saturation 47 , the final expression for the contrast becomes: …”

Section: Methodsmentioning

confidence: 99%

Off-resonance saturation as an MRI method to quantify ferritin-bound iron in the post-mortem brain

Bossoni

Hegemann-Kleinn

Duinen

et al. 2021

Preprint

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Purpose To employ an Off-Resonance Saturation (ORS) method to measure the ferritin-bound iron pool, which is an endogenous contrast agent which can give information on cellular iron status. Methods An ORS acquisition protocol was implemented on a 7T preclinical scanner and the contrast maps were fitted to an established analytical model. The method was validated by correlation and Bland-Altman analysis on a ferritin-containing phantom. Ferritin-iron maps were obtained from post-mortem tissue of patients with neurological diseases characterized by brain iron accumulation, i. e. Alzheimer's disease, Huntington's disease and aceruloplasminemia, and validated with histology. Transverse relaxation rate and magnetic susceptibility values were also obtained for comparison. Results In post-mortem tissue, the ferritin-iron contrast strongly co-localizes with histological iron staining, in all the cases. Quantitative iron values obtained via the ORS method are in agreement with literature. Conclusions Off-resonance saturation is an effective way to detect iron in grey matter structures, while mitigating for the presence of myelin. If a reference region with little iron is available in the tissue, the method can produce quantitative iron maps. This method is applicable in the study of brain diseases characterized by brain iron accumulation and complement existing iron-sensitive parametric methods.

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Imaging With Lanthanides

Peters

Djanashvili

Geraldes

2017

Comprehensive Supramolecular Chemistry II

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Improvement of the Off-Resonance Saturation, an MRI sequence for positive contrast with SPM particles: Theoretical and experimental study

Cited by 5 publications

References 47 publications

Off‐resonance saturation as an MRI method to quantify mineral‐ iron in the post‐mortem brain

Off‐resonance saturation as an MRI method to quantify mineral‐ iron in the post‐mortem brain

Off-resonance saturation as an MRI method to quantify ferritin-bound iron in the post-mortem brain

Imaging With Lanthanides

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