Improvement of the pharmacokinetic/pharmacodynamic relationship in the treatment of invasive aspergillosis with voriconazole. Reduced drug toxicity through novel rapid release formulations

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats

“…However, there were no improvements in the dissolution profile of SD-ATV (1:1.5 and 1:3) with high proportions of croscarmellose compared to SD-ATV (1:1). These changes in lipophilic drugs such as voriconazole have been studied previously [ 10 ]. The delayed dissolution profiles for SD-ATV (1:1.5) and SD-ATV (1:3) were related to a partial recrystallization of the croscarmellose.…”

“…To improve the poor solubility of EZ, surfactants such as Kolliphor RH40 have been used in micellar systems [ 7 ], while hydrophilic cellulose polymers such as Hydroxypropyl cellulose (HPC) or sodium croscarmellose have been selected for their pronounced hydrophilic properties [ 8 , 9 ] for the elaboration of solid dispersions of ATV, although EZ and ATV are difficult to quantify due to their low concentrations in liver tissue, meaning that the hepatic biodistribution of these active ingredients cannot be analyzed. Recent studies on other hydrophobic drugs such as voriconazole and amphotericin B showed a high liver biodistribution with similar micellar systems [ 10 ]. These active ingredients have shown an enterohepatic circulation, and the changes in the enterohepatic circulation of these drugs could be analyzed with an efficacy study in vivo in order to compare the differences between the formulations administered [ 11 ].…”

Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

“…This technique is based on the dispersion of poorly water-soluble drugs into a hydrophilic carrier, creating a dispersed state with improved solubility [ 12 ]. Solvent evaporation methods [ 13 , 14 ], spray drying methods [ 9 ], fusion [ 15 ], and fusion/extrusion [ 16 ] have been commonly employed for the production of solid dispersions. In many cases, the solubility increase for these systems was related to the crystallinity decrease by the inclusion of drug molecules within the carrier chains [ 14 , 17 ].…”

“…Solvent evaporation methods [ 13 , 14 ], spray drying methods [ 9 ], fusion [ 15 ], and fusion/extrusion [ 16 ] have been commonly employed for the production of solid dispersions. In many cases, the solubility increase for these systems was related to the crystallinity decrease by the inclusion of drug molecules within the carrier chains [ 14 , 17 ]. Solid dispersions with different antifungal active ingredients, such as NYS, voriconazole, or amphotericin B, have been designed to improve their solubility [ 9 , 10 , 18 ].…”

“…An increased efficacy against biofilm communities was observed with the osmotic effect of polyethylene glycol in antibiotic treatments, such as tobramycin, chloramphenicol [ 24 ], and NYS [ 10 ]. Voriconazole or clotrimazole solid dispersions with sugars such as mannitol, fructose, or dextrose showed an increased antifungal effect [ 14 , 15 ]. Furthermore, maltodextrin (MD), a hyperosmotic carrier, was studied with antifungals such as vancomycin or amphotericin B [ 21 , 26 ].…”