Improvement of the surface biocompatibility of silicone intraocular lens by the plasma‐induced tethering of phospholipid moieties

Abstract

To improve the surface biocompatibility of the silicone intraocular lens (IOL), 2-methacryloyloxyethyl phosphorylcholine (MPC) was tethered onto the IOL through air plasma treatment. Chemical changes on the IOL surface were characterized by X-ray photoelectron spectroscopy (XPS) to confirm the covalent binding of MPC. Morphologies of the IOL surfaces were observed by scanning electron microscopy (SEM) to optimize the plasma treatment process. The hydrophilicity and biocompatibility of the control and modified IOLs were compared by the measurements of water contact angle, platelet adhesion, macrophage cell culture, and lens epithelial cell (LEC) attachment. It was found that, after the tethering of MPC, the hydrophilicity of the IOL can be improved significantly and permanently, and the platelet, macrophage, and LEC adhesion on the IOL surface are obviously suppressed, which indicated the enhancement of surface biocompatibility.

Surface Modification of Hydrophobic PMMA Intraocular Lens by the Immobilization of Hydroxyethyl Methacrylate for Improving Application in Ophthalmology

“…The platelets adhesion test was performed following the method of Yao [22]. Briefly, the IOL samples were placed in 24-well polystyrene plates, sterilized with 75% ethanol, rinsed three times with phosphate-buffered saline solution (PBS) and equilibrated in PBS for 1 h. Fresh platelet-rich plasma (PRP, 20 lL) was warmed to 37°C and added to the 24-well polystyrene plates.…”

Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

“…For example, treating IOL surface with plasma or immobilizing with heparin, poly(ethylene glycol), or phosphorylcholine can reduce the bioadhesion better than coating with inert materials. [11][12][13][14][15][16] However, bioadhesion can still be found on coated hydrophilic surfaces, which may be due to the undesired surface coating by common hydrophilic molecules. A more effective antifouling coating is essential for IOL surface modifications.…”

Biomaterials for ocular reconstruction

“…One method that has been investigated to alleviate PCO is surface modification of IOLs to control the cellular response [57, [70][71][72][73]. It is widely known that material properties such as the surface chemistry, wettability and roughness can affect the cellular response [74][75][76][77].…”