1997
DOI: 10.1002/(sici)1097-0290(19970720)55:2<283::aid-bit6>3.0.co;2-e
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Improvement of the total turnover number and space-time yield for chloroperoxidase catalyzed oxidation

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Cited by 111 publications
(32 citation statements)
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“…This enzyme, a heme-containing peroxidase, has been shown to be unusually useful for selective oxygen insertion reactions which frequently occur in an enantioselective manner. This makes the enzyme a promising candidate for the production of chiral intermediates, such as epoxides, sulfoxides, or halohydrins (Kaup et al, 2007;Park and Clark, 2006;Seelbach et al, 1997;van Deurzen et al, 1997;van Rantwijk and Sheldon, 2000;van de Velde et al, 2001;Zaks and Dodds, 1995).…”
Section: Introductionmentioning
confidence: 99%
“…This enzyme, a heme-containing peroxidase, has been shown to be unusually useful for selective oxygen insertion reactions which frequently occur in an enantioselective manner. This makes the enzyme a promising candidate for the production of chiral intermediates, such as epoxides, sulfoxides, or halohydrins (Kaup et al, 2007;Park and Clark, 2006;Seelbach et al, 1997;van Deurzen et al, 1997;van Rantwijk and Sheldon, 2000;van de Velde et al, 2001;Zaks and Dodds, 1995).…”
Section: Introductionmentioning
confidence: 99%
“…This elegant and highly simplifying approach however suffers from the instability of the prosthetic heme group towards hydrogen peroxide (see also Supplementary material) [17]. Next to protein engineering [18] in situ generation of H 2 O 2 to maintain its concentration below toxic levels appears to be the most promising approach to alleviate this problem [19][20][21]. Thus, we evaluated the possibility of using the reaction cascade outlined in Scheme 1 for the generation of H 2 O 2 from formate and molecular oxygen coupled to CytC-catalyzed sulfoxidation of thioanisol.…”
mentioning
confidence: 99%
“…It is well know that high concentrations of H 2 O 2 inactivates the CPO by oxidative degradation of heme group [9,10], and thus a dosed addition of hydrogen peroxide during CPO reactions improves the catalytic efficiency [39,40]. With this variable controlled, we proceeded to select a co-solvent by favoring epoxidation reactions with hydrophobic substrates such as styrene and some of its derivatives.…”
Section: Resultsmentioning
confidence: 99%