Improvement of ursolic and oleanolic acids’ antitumor activity by complexation with hydrophilic cyclodextrins

Oprean, Constantin; Mioc, Marius; Csányi, Erzsébet; Ambrus, Rita; Bojin, Florina; Tatu, Calin A.; Cristea, Mirabela; Ivan, Alexandra; Danciu, Corina; Dehelean, Cristina; Păunescu, Virgil; Şoica, Codruţa

doi:10.1016/j.biopha.2016.08.030

Cited by 53 publications

(40 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a propolis-γCD complex possesses a less pungent taste, is water soluble, and stable to heat compared to propolis [ 23 ]. To further enhance the water solubility as well as the ability to form inclusion complexes with parent CDs, changes in their free hydroxyl groups have been made [ 24 ], resulting in CD derivatives such as 2-hydroxypropyl-γCD (HPγCD).…”

Section: Properties Of Cyclodextrinsmentioning

confidence: 99%

Cyclodextrins, Natural Compounds, and Plant Bioactives—A Nutritional Perspective

2021

View full text Add to dashboard Cite

Cyclodextrins (CDs) are a group of cyclic oligosaccharides produced from starch or starch derivatives. They contain six (αCD), seven (βCD), eight (γCD), or more glucopyranose monomers linked via α-1,4-glycosidic bonds. CDs have a truncated cone shape with a hydrophilic outer wall and a less hydrophilic inner wall, the latter forming a more apolar internal cavity. Because of this special architecture, CDs are soluble in water and can simultaneously host lipophilic guest molecules. The major advantage of inclusion into CDs is increased aqueous solubility of such lipophilic substances. Accordingly, we present studies where the complexation of natural compounds such as propolis and dietary plant bioactives (e.g., tocotrienol, pentacyclic triterpenoids, curcumin) with γCD resulted in improved stability, bioavailability, and bioactivity in various laboratory model organisms and in humans. We also address safety aspects that may arise from increased bioavailability of plant extracts or natural compounds owing to CD complexation. When orally administered, α- and βCD—which are inert to intestinal digestion—are fermented by the human intestinal flora, while γCD is almost completely degraded to glucose units by α-amylase. Hence, recent reports indicate that empty γCD supplementation exhibits metabolic activity on its own, which may provide opportunities for new applications.

show abstract

Section: Properties Of Cyclodextrinsmentioning

confidence: 99%

Cyclodextrins, Natural Compounds, and Plant Bioactives—A Nutritional Perspective

2021

View full text Add to dashboard Cite

show abstract

“…The polyurethane structures were obtained following a protocolwhich was already described in scientific literature in our previous papers [7][8][9][10][11][12][13][14][15][16][17]: The 1 st step -The preparations of the two phases…”

Section: The Obtaining Of Samplesmentioning

confidence: 99%

Obtaining and Characterization of a Polyurethane Carrier Used for Eugenol as a Possible Remedy in Oral Therapies

Popa¹,

Rusu²,

Susan³

et al. 2018

Mat.Plast.

View full text Add to dashboard Cite

The cloves are antiseptic, antiparasitic, antibacterial, antifungal, antiviral, anesthetic, analgesic, anti-inflammatory, tonic, carminative, anti-ulcer, antithrombotic, antioxidant and anti-cancerous. They contain eugenol, tannins and flavonoids that also help to strengthen the vein wall. This paper presents the obtaining and the characterization of a polyurethane drug delivery system which can be used for the transmembrane transport of eugenol in oral therapies. The products were analyzed by pH and solubility measurements, thermal decomposition and zetasizer tests and they were applied on mice skin to evaluate their harmfulness. The results suggest that were obtained neutral pH structures with low solubility and a good thermal stability, with sizes between 241 and 289 nm and no toxicity effect was found in the case of studied samples.

show abstract

“…One natural PT is Oleanolic acid (OA) ( Figure 3 ), which possesses many interesting biological activities, such as antiviral [ 18 ], anti-inflammatory, analgesic [ 18 , 19 ], antibacterial [ 20 , 21 ], anti-cancer [ 22 , 23 , 24 , 25 , 26 ], anti-oxidation [ 27 , 28 ], antimicrobial [ 29 , 30 , 31 ], and cardioprotective activities [ 32 ]. Chen et al reported that OA provides extraordinary protection against acute and chronic liver injury, and can be used as an oral medication for the treatment of human liver disorders [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activities of Oleanolic Acid and Its Analogues

2018

View full text Add to dashboard Cite

Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and herpes, are the leading causes of human death in the world. The shortage of effective vaccines or therapeutics for the prevention and treatment of the numerous viral infections, and the great increase in the number of new drug-resistant viruses, indicate that there is a great need for the development of novel and potent antiviral drugs. Natural products are one of the most valuable sources for drug discovery. Most natural triterpenoids, such as oleanolic acid (OA), possess notable antiviral activity. Therefore, it is important to validate how plant isolates, such as OA and its analogues, can improve and produce potent drugs for the treatment of viral disease. This article reports a review of the analogues of oleanolic acid and their selected pathogenic antiviral activities, which include HIV, the influenza virus, hepatitis B and C viruses, and herpes viruses.

show abstract

Improvement of ursolic and oleanolic acids’ antitumor activity by complexation with hydrophilic cyclodextrins

Cited by 53 publications

References 41 publications

Cyclodextrins, Natural Compounds, and Plant Bioactives—A Nutritional Perspective

Cyclodextrins, Natural Compounds, and Plant Bioactives—A Nutritional Perspective

Obtaining and Characterization of a Polyurethane Carrier Used for Eugenol as a Possible Remedy in Oral Therapies

Antiviral Activities of Oleanolic Acid and Its Analogues

Contact Info

Product

Resources

About