“…[2,3] Since 2014, casein has been proposed as a raw material for the formation of micro and nano capsules because of its high affinity for hydrophobic substances and is Generally Recognized as Safe (GRAS) substance [4] .Casein has been used to encapsulate different substances in the food industry. Examples of lipophilic organic substances include: omega-3 fatty acids, [5] β-carotene, [1,6,7] fish oil, [8] curcumin, [9][10][11][12] vitamin A, vitamin D, [13,14] , vanillin, [15] eugenol, [16] triclosan, [17] thymol, [18] celecoxib, [19] emodin, [20] sunflower oil, [21] resveratrol, [22,23] hydroxycamptothecin, [24] quercetin, [9] blueberry anthocyanins, [2] naringenin, [25] isoflavone, [25] rutin [4] and linoleic acid [26] ; and hydrophilic organic substances such as: vitamin C [27] and phenolic compounds . [28] On the other hand, nanoparticles of inorganic substances have been encapsulated using caseins, such as iron oxide, [29] calcium carbonate, [30] zinc oxide, [31] silver, gold and copper(II) oxide .…”