Improvement of water solubility and antibacterial activity of &lt;i&gt;Calophyllum inophyllum&lt;/i&gt; resin and calophylloidic acid A via inclusion complexation with cyclodextrins

Mizuno, Sayaka; Miyata, Ryo; Sahlan, Muhamad; Kumazawa, Shigenori

doi:10.3136/fstr.fstr-d-23-00006

Cited by 1 publication

(2 citation statements)

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“…42 Besides known compounds, a new unusual C-glycoside chromone (5,7-dihydroxychromone-3α-D-C-glucoside, named macrolobin, 55, Figure 10) was isolated from the EtOAc soluble fraction of leaves. Macrolobin (55) displayed antimicrobial activity against Pseudomonas aeruginosa and Salmonella enterica (MIC values 0.73 and 0.44 μM, respectively) and exhibited significant AChE inhibitory activity (IC 50 0.8 μM; positive control eserine 0.51 μM). 42 In accordance with the authors, these findings indicate that M. latifolium can be looked as an interesting source to find new bioactive compounds.…”

Section: Aquilaria Sinensismentioning

confidence: 99%

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Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar,

Garrido,

Borges

et al. 2024

ACS Omega

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Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in a continuous search for lead structures that can be used as models for the development of new medicines by the pharmaceutical industry. Chromone and chromanones are recognized as privileged structures and useful templates for the design of diversified therapeutic molecules with potential pharmacological interest. Chromones and chromanones are widely distributed in plants and fungi, and significant biological activities, namely antioxidant, anti-inflammatory, antimicrobial, antiviral, etc., have been reported for these compounds, suggesting their potential as lead drug candidates. This review aims to update the literature published over the last 6 years (2018–2023) regarding the natural occurrence and biological activity of chromones and chromanones, highlighting the recent findings and the perspectives that they hold for future research and applications namely in health, cosmetic, and food industries.

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Section: Aquilaria Sinensismentioning

confidence: 99%

“…acid B(71) 55. Among these new compounds, only the last one showed significant biological activity, exhibiting potent antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 16 and 8 μg/mL, respectively.…”

mentioning

confidence: 99%