Improvement on blood pressure and skin using roselle drink: A clinical trial

Abstract

Roselle (Hibiscus sabdariffa L.) is an increasingly attractive plant for its health and pharmaceutical, beverage, and cosmetic applications. The purpose of this study was to investigate the clinical effects of roselle drink on antioxidant activity, blood pressure, and skin condition. Roselle drink used in this study contained rich phenolics (1.96 g of gallic acid equivalent/100 ml) and anthocyanins (1.65 g of cyanidin‐3‐glucoside equivalent/100 ml). In a randomized, cross‐over, double‐blind, placebo‐controlled clinical study, 39 healthy adults received drank 200 ml of roselle drink or placebo‐control drink for 6 months. A significant reduction in the blood pressure was observed in the roselle drink treated group when compared with preintervention values. After 6 months of treatment with roselle drink, serum phenolics contents, the levels of Trolox equivalent antioxidant capacity (TEAC), glutathione, superoxide dismutase (SOD), glucose‐6‐phosphate dehydrogenase (G‐6‐PDH), glutathione peroxidase (GSH‐Px), and glutathione reductase (GSH‐Rd) were significantly increased in healthy subjects. However, a significant increment in skin redness and skin moisture was observed in the facial skin of roselle drink‐treated participants. Oral administration of roselle drink for 6 months significantly lowered the blood pressure, improved antioxidation level, and positively regulated skin redness as well as moisture. Phenolics and anthocyanins in roselle could be the major potential contributors to such health effects. Practical applications Roselle is a typical plant. Continuous administration of roselle drink clearly improved antioxidation levels, reduced blood pressure and positively regulated skin redness and moisture. Phenloics and anthocyanins in roselle could be the major potentila contributors of such health benefits.

Phytochemical Composition and Inhibitory Activities of Hibiscus sabdariffa and Cucumis sativus Infusions Against Angiotensin-Converting Enzyme

“…[5][6][7] Previous studies showed that H. sabdariffa contains anthocyanins, flavonoids, phenolic compounds, glycosides, tannins, alkaloids, terpenoids, vitamin C, and organic acids, [8][9][10] which can be useful as antioxidants, 11,12 antibacterials, 9 antidiabetics, 13 anti-inflammatory agents and immunomodulators, 14 and anticancer agents. 15 Previous research also showed that H. sabdariffa helps lower cholesterol levels, 16,17 reduce obesity, 18 lower blood pressure, [19][20][21][22] and improve kidney function in people with hypertension. 24,25 and is rich in cucurbitacins (terpenoids), 26,27 which can be useful as antibacterial and anticancer, 28 anti-inflammatory, 29,30 and antihypertensive agents, 7 as well as helping wound healing, 31 and reducing pain in osteoarthritis.…”

Potential Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports

“…To date, non-steroidal anti-inflammatory agents and diseasemodifying anti-rheumatic drugs, like immunosuppressants and monoclonal antibodies (e.g., rituximab and tocilizumab) combined with methotrexate, have been largely used to attenuate RA; however, most of them are expensive, rarely effective or tolerable, and lead to several unwanted effects, including allergy and infections, gastrointestinal problems, fluid retention, renal dysfunction and systemic vasculitis, cytopenia, lymphopenia, neutropenia, and the elevation of transaminase and cholesterol [7][8][9][10][11][12][13]. Among the new and most promising availability strategies, special attention has been given to bioactive molecules largely found in nature, namely, polyphenols, since their chemical structure with catechol methoxy and pyrogallol groups confer them notable health benefits, like antioxidant, anti-inflammatory, anti-bacterial, and antiproliferative activities, as well as the capacity to prevent neurological and cardiovascular pathologies, promote gastrointestinal health and vision without, it is believed, side-effects, and enhance wound healing [14][15][16][17][18][19][20][21][22][23]. In addition, polyphenols are also easier to obtain, water-soluble, and more economical than chemical drugs, and have already shown effectiveness in inhibiting JAK proteins and JAK/STAT signaling pathways [24][25][26][27][28].…”

Antioxidant, enzymes inhibitory, physicochemical and sensory properties of instant bio-yoghurts containing multi-purpose natural additives

“…It contains anthocyanins, organic acids, and ascorbic acid (40, 41). Its phytoconstituents have been found to have anti-diarrheal, antispasmodic, anti-hypertensive, and anti-inflammatory activities (39,(42)(43)(44).…”