Improvements and considerations for size distribution retrieval from small-angle scattering data by Monte Carlo methods

Pauw, Brian R.; Pedersen, Jan Skov; Tardif, Samuel; Takata, Masaki; Iversen, Bo B.

doi:10.1107/s0021889813001295

Cited by 97 publications

(126 citation statements)

References 27 publications

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“…Uncertainties allow for the weighting of the data to their uncertainty, so that accurate datapoints weigh more heavily in least-squares optimization than datapoints with large uncertainties. Furthermore, the provision of uncertainties allows for determination of a goodness of fit value which indicates whether or not the model fits the data (on average) to within the uncertainty of the data [137,133]. A lack of uncertainties does not allow any further evaluation of a model than an estimation by eye, whose analysis capabilities are easily swayed by the choice of axes and datapoint size.…”

Section: What's Next? a Few Words On Data Fittingmentioning

confidence: 99%

Everything SAXS: small-angle scattering pattern collection and correction

Pauw

2013

J. Phys.: Condens. Matter

169

136

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Section: What's Next? a Few Words On Data Fittingmentioning

confidence: 99%

Everything SAXS: small-angle scattering pattern collection and correction

Pauw

2013

J. Phys.: Condens. Matter

169

136

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“…We found that the simplest model for interpretation of all data was that of spherical particle morphology. Their size distribution was retrieved by employing a Monte Carlo SAXS data evaluation procedure recently published by Pauw et al, (2013). The main advantage of this procedure is that no size distribution type such as Gaussian, Schultz-Zimm, etc., needs to be assumed a priori.…”

Section: Particle Characterizationmentioning

confidence: 99%

Impact of food components during in vitro digestion of silver nanoparticles on cellular uptake and cytotoxicity in intestinal cells

Lichtenstein

Ebmeyer

Knappe

et al. 2015

Biological Chemistry

121

125

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Because of the rising application of nanoparticles in food and food-related products, we investigated the influence of the digestion process on the toxicity and cellular uptake of silver nanoparticles for intestinal cells. The main food components--carbohydrates, proteins and fatty acids--were implemented in an in vitro digestion process to simulate realistic conditions. Digested and undigested silver nanoparticle suspensions were used for uptake studies in the well-established Caco-2 model. Small-angle X-ray scattering was used to estimate particle core size, size distribution and stability in cell culture medium. Particles proved to be stable and showed radii from 3.6 to 16.0 nm. Undigested particles and particles digested in the presence of food components were comparably taken up by Caco-2 cells, whereas the uptake of particles digested without food components was decreased by 60%. Overall, these findings suggest that in vivo ingested poly (acrylic acid)-coated silver nanoparticles may reach the intestine in a nanoscaled form even if enclosed in a food matrix. While appropriate for studies on the uptake into intestinal cells, the Caco-2 model might be less suited for translocation studies. Moreover, we show that nanoparticle digestion protocols lacking food components may lead to misinterpretation of uptake studies and inconclusive results.

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“…2 ), 32 which most SANS fitting programs provide. This is particularly applicable to SANS on complicated systems for the aforementioned reasons.…”

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confidence: 99%

Practical applications of small-angle neutron scattering

Hollamby

2013

Phys. Chem. Chem. Phys.

124

116

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Recent improvements in beam-line accessibility and technology have led to small-angle neutron scattering (SANS) becoming more frequently applied to materials problems. SANS has been used to study the assembly, dispersion, alignment and mixing of nanoscale condensed matter, as well as to characterise the internal structure of organic thin films, porous structures and inclusions within steel.Using time-resolved SANS, growth mechanisms in materials systems and soft matter phase transitions can also be explored. This review is intended for newcomers to SANS as well as experts. Therefore, the basic knowledge required for its use is first summarised. After this introduction, various examples are given of the types of soft and hard matter that have been studied by SANS. The information that can be extracted from the data is highlighted, alongside the methods used to obtain it. In addition to presenting the findings, explanations are provided on how the SANS measurements were optimised, such as the use of contrast variation to highlight specific parts of a structure. Emphasis is placed on the use of complementary techniques to improve data quality (e.g. using other scattering methods) and the accuracy of data analysis (e.g. using microscopy to separately determine shape and size). This is done with a view to providing guidance on how best to design and analyse future SANS measurements on materials not listed below.

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Improvements and considerations for size distribution retrieval from small-angle scattering data by Monte Carlo methods

Cited by 97 publications

References 27 publications

Everything SAXS: small-angle scattering pattern collection and correction

Everything SAXS: small-angle scattering pattern collection and correction

Impact of food components during in vitro digestion of silver nanoparticles on cellular uptake and cytotoxicity in intestinal cells

Practical applications of small-angle neutron scattering

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