Improvements in carotid plaque imaging using a new eight‐element phased array coil at 3T

Balu, Niranjan; Yarnykh, Vasily L.; Scholnick, Joshua; Chu, Baocheng; Yuan, Chun; Hayes, Cecil E.

doi:10.1002/jmri.21890

Cited by 55 publications

(46 citation statements)

References 33 publications

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“…All examinations were performed on a 3T MR imaging scanner (Achieva; Philips Healthcare, Best, the Netherlands) by using either a 4-channel (Pathway MR Imaging, Redmond, Washington) or an 8-channel 19 phased-array carotid coil. For the CE-MRA series, a 3D FFE sequence was acquired before (ie, mask) and after the intravenous injection of gadopentetate dimeglumine (0.1 mmol/kg, Magnevist; Schering, Berlin, Germany) or gadodiamide (Omniscan; GE Healthcare, Piscataway, New Jersey) in the coronal plane with the following parameters: TR/TE/flip angle, 6.0 ms/2.0 ms/30°; bandwidth, 434 Hz/pixel; matrix, 392 × 392; FOV, 260 × 260 mm 2 ; 40 sections.…”

Section: Methodsmentioning

confidence: 99%

Identification of Intraplaque Hemorrhage on MR Angiography Images: A Comparison of Contrast-Enhanced Mask and Time-of-Flight Techniques

Qiao¹,

Etesami²,

Malhotra³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE MRA is widely used to measure carotid narrowing. Standard CE- and TOF-MRA techniques use highly T1-weighted gradient-echo sequences that can detect T1 short blood products, so they have the potential to identify IPH, an indicator of plaque rupture. We sought to determine the accuracy and reliability of these MRA sequences to detect IPH. MATERIALS AND METHODS 3D TOF and CE carotid MRA scans were obtained at 3T on 15 patients (age range, 58–86 years; 13 men) scheduled for CEA. The source images from the precontrast (mask) CE-MRA and the TOF sequences were reviewed by 2 independent readers for IPH presence (identified as hyperintense signal intensity compared with adjacent muscle). CEA specimens were stained with antibody against glycophorin A and Mallory stain to detect IPH and were correlated with MR images. RESULTS Nine of 15 CEA specimens (61 of 144 MR images) contained IPH confirmed by histology. Compared with TOF, CE-MRA mask demonstrated greater sensitivity, specificity, PPV, and NPV for IPH detection. The accuracy for correctly identifying IPH by using CE-MRA mask images and TOF images was 94% and 84%, respectively. Inter- and intraobserver agreement for IPH detection was excellent by mask images (κ = 0.91 and κ = 0.94, respectively) and TOF images (κ = 0.77 and κ = 0.84, respectively). CONCLUSIONS CE-MRA mask images are highly accurate and reliable for identifying IPH, more so than the TOF sequence, and can potentially provide valuable information about risk for rupture.

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Section: Methodsmentioning

confidence: 99%

Identification of Intraplaque Hemorrhage on MR Angiography Images: A Comparison of Contrast-Enhanced Mask and Time-of-Flight Techniques

Qiao¹,

Etesami²,

Malhotra³

et al. 2011

AJNR Am J Neuroradiol

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“…16 Images were centered at the carotid bifurcation of the index artery, which was defined in the diseased group as the artery with the greatest degree of lumen area reduction as seen on an axial two-dimensional time-of-flight (TOF) MR angiogram (MRA). The left carotid bifurcation was selected as index side for the healthy participants.…”

Section: Iia Magnetic Resonance Imaging Datamentioning

confidence: 99%

Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging

et al. 2012

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Purpose: Arterial distensibility is a marker that can measure vessel wall functional and structural changes resulting from atherosclerosis with applications including estimation of mechanical properties of the wall. We sought to assess the feasibility of using magnetic resonance imaging (MRI) to include wall distensibility in the characterization of atherosclerotic carotid arteries and to analyze the relationship between distensibility and morphological and compositional plaque features. Methods: Five healthy volunteers were imaged with a multiple-slice CINE MR sequence twice, within 24 h, to determine the interscan reproducibility of distensibility measurements. Twenty-one subjects with >15% carotid stenosis and the five healthy volunteers were imaged using a multicontrast carotid MRI protocol to characterize arterial wall morphology and composition. Normalized wall index (wall area/total vessel area), maximum wall thickness and, if present, percentages of wall area occupied by calcification and lipid-rich necrotic core were determined. A multiple-slice CINE MR sequence was added to the multicontrast protocol to measure the distensibility coefficient (DC) at several locations spanning the bifurcation. The intraclass correlation coefficient (ICC) and the coefficient of variation were used to assess the reproducibility of DC measurements made on the healthy subjects. The DC was compared between arterial segments and between the healthy and diseased groups. Furthermore, within the diseased group, DC was correlated to plaque morphology and composition at each location as well as that averaged over the plaque. Results: Distensibility measurements were highly reproducible: ICC (95% confidence interval) was 0.998 (0.96-1.0) for the common carotid segment and 0.990 (0.92-1.0) for the internal carotid segment. In healthy volunteers, we found significantly higher distensibility in the common segment of the carotid artery compared to the internal carotid segment (mean ± SD = 4.56 ± 1.02 versus 3.56 ± 1.32 × 10 −5 /Pa; p < 0.05). However, no segmental differences were seen in the diseased group (3.25 ± 1.84 versus 3.26 ± 1.60 × 10 −5 /Pa; p = 0.607). Location-to-location changes in DC were not found to correlate to changes in the local plaque morphology or composition nor were average DC found to be associated with aggregate plaque features.Conclusions: These results demonstrate the feasibility of MRI to measure distensibility in the carotid artery and to presumably detect changes in distensibility due to age and/or disease. The results suggest that the effect of atherosclerosis on local distensibility may not strongly depend upon the specific underlying plaque features in mild to moderate stenotic carotid lesions though more diffuse or nonlocal changes in arterial distensibility could not be ruled out.

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“…All scans were performed at 3.0 T using commercially available carotid phased-array coils (GE: 6-channel, Neocoil LLC, Pewaukee, WI, USA; Philips: 8-channel, Shanghai Chenguang Medical Technologies, Shanghai, China) [20]. A standardized MRI protocol was implemented on both platforms with carefully matched sequences and parameters, which acquires multi-contrast, cross-sectional images around the carotid bifurcation (Supplemental Table 2).…”

Section: Methodsmentioning

confidence: 99%

Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study

Sun

Zhao

Balu

et al. 2014

Int J Cardiovasc Imaging

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This study sought to determine the multicenter reproducibility of magnetic resonance imaging (MRI) and the compatibility of different scanner platforms in assessing carotid plaque morphology and composition. A standardized multi-contrast MRI protocol was implemented at 16 imaging sites (GE: 8; Philips: 8). Sixty-eight subjects (61 ± 8 years; 52 males) were dispersedly recruited and scanned twice within 2 weeks on the same magnet. Images were reviewed centrally using a streamlined semiautomatic approach. Quantitative volumetric measurements on plaque morphology (lumen, wall, and outer wall) and plaque tissue composition [lipid-rich necrotic core (LRNC), calcification, and fibrous tissue] were obtained. Inter-scan reproducibility was summarized using the within-subject standard deviation, coefficient of variation (CV) and intraclass correlation coefficient (ICC). Good to excellent reproducibility was observed for both morphological (ICC range 0.98–0.99) and compositional (ICC range 0.88–0.96) measurements. Measurement precision was related to the size of structures (CV range 2.5–4.9 % for morphology, 36–44 % for LRNC and calcification). Comparable measurement variability was found between the two platforms on both plaque morphology and tissue composition. In conclusion, good to excellent inter-scan reproducibility of carotid MRI can be achieved in multicenter settings with comparable measurement precision between platforms, which may facilitate future multicenter endeavors that use serial MRI to monitor atherosclerotic plaque progression.

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Improvements in carotid plaque imaging using a new eight‐element phased array coil at 3T

Cited by 55 publications

References 33 publications

Identification of Intraplaque Hemorrhage on MR Angiography Images: A Comparison of Contrast-Enhanced Mask and Time-of-Flight Techniques

Identification of Intraplaque Hemorrhage on MR Angiography Images: A Comparison of Contrast-Enhanced Mask and Time-of-Flight Techniques

Characterization of distensibility, plaque burden, and composition of the atherosclerotic carotid artery using magnetic resonance imaging

Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study

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