2007
DOI: 10.1016/j.ijms.2007.02.036
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Improvements in quantitative chiral determinations using the mass spectrometric kinetic method

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Cited by 28 publications
(29 citation statements)
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“…[9][10][11] In the third approach, based on the application of "Cooks Kinetic Method", [12][13][14] collision-induced dissociation (CID) of a proton-or a metal-bound complex formed between a chiral analyte and an optically pure reference leads to the loss either of the reference or of the analyte, and the branching ratio (BR) of the fragments can be used to determine the enantiomeric composition of the analyte. [15] In none of the above cases, however, is chiral discrimination connected to a fundamental chemical process-making or breaking of covalent bonds, for example-within one of the complexs building blocks.…”
Section: Introductionmentioning
confidence: 99%
“…[9][10][11] In the third approach, based on the application of "Cooks Kinetic Method", [12][13][14] collision-induced dissociation (CID) of a proton-or a metal-bound complex formed between a chiral analyte and an optically pure reference leads to the loss either of the reference or of the analyte, and the branching ratio (BR) of the fragments can be used to determine the enantiomeric composition of the analyte. [15] In none of the above cases, however, is chiral discrimination connected to a fundamental chemical process-making or breaking of covalent bonds, for example-within one of the complexs building blocks.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have been pursued to isolate and characterise them at the molecular level, without the perturbations brought by the environment [15]. In this respect, mass spectrometry (MS) brings decisive contribution for the study of asymmetric catalysts or molecules used as Chiral Stationary Phases (CSP), in isolated conditions [16,17]. Coupled to electrosprays or MALDI sources, it makes possible the study of systems of sizeable dimension, close to the real systems, at room temperature.…”
Section: A Zehnackermentioning
confidence: 99%
“…In well-defined experimental conditions, Collision-Induced Dissociation (CID) of trimeric cationic clusters (M II (A)(R*) 2 -H) + which contain a divalent metal M II , a chiral reference R* and the analyte A, provides similar information [29][30][31][32][33][34]. It is possible to compare the efficiency of ejection of the chiral reference R* and the analyte A from the complex, for the two enantiomers A R and A S in the so-called Kinetic Method or its variant [16,29,35]. Recently, Ion Mobility [36,37] or Electron-Capture Dissociation have also been applied to chiral recognition [38].…”
Section: A Zehnackermentioning
confidence: 99%
“…The fast and sensitive performance of mass spectrometry (MS) places it among the most promising techniques in drug analysis. However, despite significant success in the development of MS-based chiral recognition methods [7][8][9][10][11][12][13][14][15], many gas-phase processes which lie behind this recognition are still poorly understood.…”
Section: Introductionmentioning
confidence: 99%