Improvements to mechanical response tissue analysis

Bowman, Lyn; Loucks, Anne B.

doi:10.1016/j.mex.2019.10.004

Cited by 4 publications

(11 citation statements)

References 14 publications

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“… 39 Despite these promising data, MRTA was never successfully commercialized for numerous reasons, some of which related to the technology having several sources of error. 31 , 40-42 For instance, the original MRTA design was highly sensitive to probe placement and lacked robust mechanical grounds (or end conditions) needed for conducting a rigorous 3-point bend test.…”

Section: Introductionmentioning

confidence: 99%

“…This resurgence capitalizes on structural vibration analysis of bone in its reinvented 21st century form – Cortical Bone Mechanics Technology (CBMT). 40 Cortical Bone Mechanics Technology incorporates several noteworthy improvements, such as the integration of robotics and machine intelligence to (1) collect data at multiple sites across the mid-shaft of the ulna bone in the forearm, overcoming issues around probe placement and (2) employ novel algorithms to real-time recognition of distinctive features in accurate data. 13 , 40 Furthermore, the hardware design of CBMT has been refined to provide adjustable and stable end conditions, ensuring a more idealized 3-point bend test (refer to the "Methods” section for additional details).…”

Section: Introductionmentioning

confidence: 99%

“…Cortical Bone Mechanics Technology utilizes multifrequency vibration analysis to conduct a noninvasive, dynamic 3-point bending test, enabling direct and functional mechanical measurements of ulnar cortical bone, such as flexural rigidity. 13 , 40 As a whole bone test, CBMT’s measurements reflect the combined influences of bone quantity, structure, and quality at all hierarchical levels. 13 , 40 Its validity in accurately measuring ulna flexural rigidity and estimating quasistatic ulna bending strength has been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“… 13 , 40 As a whole bone test, CBMT’s measurements reflect the combined influences of bone quantity, structure, and quality at all hierarchical levels. 13 , 40 Its validity in accurately measuring ulna flexural rigidity and estimating quasistatic ulna bending strength has been demonstrated. 40 , 43 Cortical Bone Mechanics Technology-derived flexural rigidity provided a near perfect estimate of cadaveric bone strength ( R 2 = 0.99).…”

Section: Introductionmentioning

confidence: 99%

“… 13 , 40 Its validity in accurately measuring ulna flexural rigidity and estimating quasistatic ulna bending strength has been demonstrated. 40 , 43 Cortical Bone Mechanics Technology-derived flexural rigidity provided a near perfect estimate of cadaveric bone strength ( R 2 = 0.99). 43 Moreover, flexural rigidity of human cadaveric bone, as measured by CBMT, decreased by 21% following potassium hydroxide-induced collagen degradation, while BMD remained unaltered.…”

Section: Introductionmentioning

confidence: 99%

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Fracture discrimination capability of ulnar flexural rigidity measured via Cortical Bone Mechanics Technology: study protocol for The STRONGER Study

Warden,

Dick,

Simon

et al. 2024

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Osteoporosis is characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility (i.e., weakness) and an increased risk for fracture. The current standard for assessing bone health and diagnosing osteoporosis is dual-energy x-ray absorptiometry (DXA), which quantifies areal bone mineral density (BMD), typically at the hip and spine. However, DXA-derived BMD assesses only one component of bone health and is notably limited in evaluating bone strength, a critical factor in fracture resistance. Although multifrequency vibration analysis can quickly and painlessly assay bone strength, there has been limited success in advancing a device of this nature. Recent progress has resulted in the development of Cortical Bone Mechanics Technology (CBMT), which conducts a dynamic 3-point bending test to assess the flexural rigidity (EI) of ulnar cortical bone. Data indicates that ulnar EI accurately estimates ulnar whole bone strength and provides unique and independent information about cortical bone compared to DXA-derived BMD. Consequently, CBMT has the potential to address a critical unmet need: better identification of patients with diminished bone strength who are at high risk of experiencing a fragility fracture. However, the clinical utility of CBMT-derived EI has not yet been demonstrated. We have designed a clinical study to assess the accuracy of CBMT-derived ulnar EI in discriminating post-menopausal women who have suffered a fragility fracture from those who have not. These data will be compared to DXA-derived peripheral and central measures of BMD obtained from the same subjects. In this article, we describe the study protocol for this multi-center fracture discrimination study (The STRONGER Study).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fracture discrimination capability of ulnar flexural rigidity measured via Cortical Bone Mechanics Technology: study protocol for The STRONGER Study

Warden,

Dick,

Simon

et al. 2024

JBMR Plus

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In Vivo Assessment of Cortical Bone Fragility

Bowman

Loucks

2020

Curr Osteoporos Rep

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Purpose of Review This review updates readers on recent developments in the assessment of cortical bone fragility in vivo. The review explains the clinical need that motivated the development of Cortical Bone Mechanics Technology™ (CBMT) as a scientific instrument, its unique capabilities, and its necessary further development as a medical device. Recent Findings Clinical experience with dual-energy X-ray absorptiometry has led to calls for new clinical methods for assessing bone health. CBMT is a noninvasive, dynamic 3-point bending test that makes direct, functional measurements of the mechanical properties of cortical bone in ulnas of living people. Its technical validity in accurate measurements of ulna flexural rigidity and its clinical validity in accurate estimations of quasistatic ulna bending strength have been demonstrated. Summary Because CBMT is a whole bone test, its measurements reflect the influences of bone quantity and bone quality at all hierarchical levels.

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