Concerns have been raised that the DSM-IV requirements of six-month duration, excessive worry, and three associated symptoms exclude a substantial number of people with clinically significant anxiety from a diagnosis of generalized anxiety disorder (GAD). We examined the implications of relaxing these three criteria for the estimated prevalence and predictive validity of GAD using nationally representative data from the US National Comorbidity Survey Replication. Relaxing all three criteria more than doubles the estimated prevalence of GAD. Broadly-defined GAD significantly predicts the subsequent first onset of a wide range of temporally secondary disorders. The odds of secondary disorders are somewhat smaller for broadly-defined than DSM-IV GAD, though few of these differences are statistically significant. Results suggest that subthreshold manifestations of GAD are significantly related to elevated risk of subsequent psychopathology. Further research is needed to determine whether broadening the current diagnostic criteria results in a more valid characterization of GAD.
Keywordsgeneralized anxiety disorder; prevalence; epidemiology; comorbidity; classification The diagnostic definition of generalized anxiety disorder (GAD) has been a source of debate since the disorder was first introduced in the third edition of the Diagnostic and Statistical Manual of Mental disorders (DSM-III) (American Psychiatric Association, 1980). Given the challenges of distinguishing generalized anxiety from normal stress reactions and from other anxiety and mood disorders (Barlow et al., 1986;Breslau & Davis, 1985; Correspondence concerning this article should be addressed to Ayelet Meron Ruscio, who is now at the Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA, USA 19104. Voice: 215-573-4113; Fax: 215-898-7301; E-mail: ruscio@psych.upenn.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1994), it is perhaps not surprising that the definition of GAD has changed substantially with each subsequent DSM revision. DSM-III defined GAD as one month of persistent anxiety accompanied by associated symptoms from three of four categories. DSM-III-R changed the requirements to six months of worry along with six of 18 associated symptoms to improve the validity of separation from normal anxiety and from anxiety that occurs secondary to other mental disorders (American Psychiatric Association, 1987). DSM-IV made further changes aimed at sharpening the characterization of GAD by requiring that worry be excessive and uncontrollable (American Psychia...