Despite best efforts, integrated systems are "born" (manufactured) with a unique 'personality' that stems from our inability to precisely fabricate their underlying circuits, and create software a priori for controlling the resulting uncertainty. It is possible to use sophisticated test methods to identify the bestperforming systems but this would result in unacceptable yields and correspondingly high costs. The system personality is further shaped by its environment (e.g., temperature, noise and supply voltage) and usage (i.e., the frequency and type of applications executed), and since both can fluctuate over time, so can the system's personality. Systems also "grow old" and degrade due to various wear-out mechanisms (e.g., negative-bias temperature instability), and unexpectedly due to various early-life failure sources. These "nature and nurture" influences make it extremely difficult to design a system that will operate optimally for all possible personalities. To address this challenge, we propose to develop statistical learning in-chip (SLIC). SLIC is a holistic approach to integrated system design based on continuously learning key personality traits on-line, for selfevolving a system to a state that optimizes performance hierarchically across the circuit, platform, and application levels. SLIC will not only optimize integrated-system performance but also reduce costs through yield enhancement since systems that would have before been deemed to have weak personalities (unreliable, faulty, etc.) can now be recovered through the use of SLIC.