Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts

Xu, Xiuhong; Guo, Shangwei; Hao, Xianghui; Ma, Hongan; Bai, Yanping; Huang, Yaqin

doi:10.1002/fsn3.587

Cited by 17 publications

(7 citation statements)

References 38 publications

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“…As a result, antioxidants can reduce oxidative stress and subsequently certain chronic diseases such as cancer and diabetes. Despite the effectiveness of synthetic molecules, their use has presented undesirable side effects on health [32]. As a result, secondary metabolites derived from medicinal plants could provide a safe antioxidant potential.…”

Section: Antioxidant Capacitymentioning

confidence: 99%

Beta vulgaris subsp. maritima: A Valuable Food with High Added Health Benefits

et al. 2022

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The present study was conducted to evaluate a natural extract, obtained from the Beta vulgaris plant, for its phytochemical composition and its beneficial health effects. Therefore, total phenolic and flavonoid contents, as well as identification and quantification of phenolic compounds by HPLC, were assessed in leaves’ extract. Moreover, antioxidant activities were investigated using free radical scavenging tests, (ABTS+ and DPPH+) and reducing power assay (FRAP) as well as ferrous ions’ (Fe2+) chelating activity. The Antiglycation effect was also evaluated, using the BSA-fructose model, and the antidiabetic effect was determined by inhibition of α-amylase and α-glucosidase enzymes. Additionally, the in vitro antitumor effect was quantified using the MTT assay, and the antibacterial activity was evaluated using the agar disc diffusion and broth microdilution methods. Both aqueous and methanolic extracts exhibited potential antioxidant capacity with a higher effect for the methanolic extract. Furthermore, the in vitro antitumor activity of the methanolic extracts exhibited potent cytotoxic effects against two breast cancer cell lines, MDA-MB-468 and MCF-7. Moreover, Beta vulgaris extracts inhibit not only α-amylase and α-glucosidase, but also advanced glycation end-products’ (AGEs) formation, which would prevent diabetes’ complications. Beta vulgaris methanolic extract revealed also a high antibacterial effect against Proteus mirabilis and Bacillus subtilis. Taken together, these results revealed that Beta vulgaris leaves’ extracts constitute a valuable food and natural source of bioactive molecules that could be used for the development of new, natural drugs against cancer and diabetes.

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Section: Antioxidant Capacitymentioning

confidence: 99%

Beta vulgaris subsp. maritima: A Valuable Food with High Added Health Benefits

et al. 2022

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“…Del análisis aproximado del subproducto se logró identificar que en su composición contiene varios productos de interés comercial, estos resultados coincidieron con los estudios informados anteriormente [2,25]. La especificidad de las enzimas es un elemento primario que influye en las características de los hidrolizados, es decir, la composición y las secuencias de aminoácidos de los péptidos producidos dependerán en gran medida del tipo de proteasa y sustrato que se haya utilizado [10,11,26]. El aumento del GH estuvo de acuerdo con informes previos de hidrólisis de proteínas donde GH se mejoró con el aumento de las cantidades de enzimas [27][28][29], esto indica el porcentaje de enlaces peptídicos rotos en relación con la proteína original.…”

Section: Discusionesunclassified

“…Estos productos alimenticios como las bebidas proteicas que existen en el mercado son ricos en proteínas y péptidos, y son obtenidas por este método [9]. Un hidrolizado está determinado por el grado de hidrólisis y la especificidad de las enzimas, que permite determinar sus características y, por lo tanto, sus posibles aplicaciones [10][11][12][13][14][15]. Para este propósito, en este trabajo describimos un proceso biotecnológico para obtener hidrolizados de proteínas a partir de subproductos de la industria de los hongos comestibles basados en el uso de proteasas, debido a su bajo costo, alto valor nutricional y excelente biocompatibilidad que puede ser potencialmente útil en agronomía y en cosmética.…”

Section: Introductionunclassified

Obtaining Protein Hydrolyzates By-products of Agaricus Bisporus

Inca-Torres

Urbina-Salazar

Inca-Torres³

et al. 2021

espoch

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The mushroom industry generates non-marketable by-products that are not used or misused, these by-products are rich in protein and other beneficial compounds for health. Currently there is great interest in products rich in protein from agro-industrial waste, in this study was used mushroom by-products to obtain protein concentrates and isolates in order to improve functional properties, using a biotechnological process based on the use of proteases, with an effective approach for the maximum recovery of the components, maintaining their quality and effectiveness. It was used 4 different proteases (Alcalasa®, Flavourzyme®, Papain and Bioprotease LA-450) to determine which of them is most effective, the most efficient proteases that lead to a higher hydrolysis degree is used Bioprotease LA-450 and Alcalasa® (6.65 ± 0.6 and 6.21 ± 0.9) respectively, obtaining a higher amount of solubilized products (46.3 ± 3.6% and 41.7 ± 3%), as well as the Bioprotease LA-450, who presents a higher content of total proteins (51. 9 ± 4.8). This hydrolyzate, due to its composition: rich in amino acids, oligopeptides and peptides, can be used as a biofertilizer in agronomy, and as a nutraceutical or nutricosmetic in food or cosmetics. Keywords: Agaricus bisporus, Enzymes, Protein hydrolysates, By-product. Resumen La industria del champiñón genera subproductos no comercializables que no se utilizan o mal utilizan, estos subproductos son ricos en proteínas y otros compuestos beneficiosos para la salud. Actualmente existe gran interés en los productos ricos en proteína provenientes de residuos agroindustriales, en este estudio se utilizó los subproductos del champiñón para obtener concentrados y aislados de proteínas con el fin de mejorar las propiedades funcionales, utilizando un proceso biotecológico basado en el uso de proteasas, con un enfoque efectivo para la recuperación máxima de los componentes, manteniendo su calidad y efectividad. Se usó 4 diferentes proteasas (Alcalasa®, Flavourzyme®, Papaína y Bioproteasa LA-450) para determinar cuál de ellas es la más efectiva, las proteasas más eficientes que conducen a un mayor grado de hidrólisis es cuando se utilizan la Bioproteasa LA-450 y la Alcalasa® (6,65 ± 0,6 y 6,21 ± 0,9) respectivamente, obteniéndose mayor cantidad de productos solubilizados (46,3 ± 3,6% y 41,7 ± 3%), así como la Bioproteasa LA-450 que presenta mayor contenido de proteínas totales (51,9±4,8). Este hidrolizado debido a su composición: rico en aminoácidos, oligopéptidos y péptidos puede ser utilizado como biofertilizante en agronomía, y nutracéutico o nutricosmético en alimentación o cosmética. Palabras Clave: Agaricus bisporus, Enzimas, Hidrolizados proteicos, Subproducto.

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“…The most benefits associated with the use of food rich in polyphenols include a reduced risk of coronary diseases and prevention of cancer and some neurodegenerative diseases. [39][40][41] Ginkgo biloba extract is obtained from green leaf and has several properties as phychoanaleptic against dementia. It contains two bioactive components, a glucoside flavonoide and a lactone from terpenes (trilactone), denominated ginkgolides and bilobalide.…”

Section: Ginkgo Bilobamentioning

confidence: 99%

Plants with evidence-based therapeutic effects against neurodegenerative diseases

Benedı́

Bermejo-Bescós

et al. 2019

PPIJ

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Neurodegenerative diseases are a group of illnesses, which affect both central and peripheral nervous system inducing physiological dysfunctions related with loss of movements and mental integrity, among others. In general, these diseases are incurable and only few drugs may alleviate the symptomatology or prolong the survival of patients. In this setting, medicinal plants might constitute adjuvant therapies with conventional pharmacotherapeutics in order to reduce or remedy the neurodegenerative illness. The aim of this review is to present the neuropharmacological activity of some phytochemicals from noteworthy medicinal plants that have been used in traditional medicine. Particularly, we will focus on medicinal plants with evidence-based therapeutic effects against neurodegenerative diseases. Crucial among these plants is Daphne Genkwa, with its active components genkwanine N and yuanhuacin, which are both able to activate the transcriptional function of the Nurr1 receptor. Another plant to be highlighted is Jatropha multifida containing apocynin, a selective inhibitor of the phagocyte NADPH oxidase. Galanthus nivalis is a remarkable plant for its content in galantamine, an inhibitor of the acetylcholinesterase enzyme and an inhibitor of the nicotinic acetylcholine receptor (nAChR) with a mechanism consistent with open-channel pore blockade. Galantamine is currently used in Alzheimer's disease and dementias. Ginkgo biloba is known for its leaves as a natural source of flavonoids and polyphenolic compounds and it is used in the treatment of progressive neurodegenerative disorders such as Alzheimer's disease. Glycine max or soybeans contain isoflavones such as genistein, daidzein and glycitein. Among these phytochemicals, genistein should be underlined for its potential to alleviate neurological symptoms present in most lysosomal storage diseases by decreasing the biosynthesis of accumulating substrates.

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Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts

Cited by 17 publications

References 38 publications

Beta vulgaris subsp. maritima: A Valuable Food with High Added Health Benefits

Beta vulgaris subsp. maritima: A Valuable Food with High Added Health Benefits

Obtaining Protein Hydrolyzates By-products of Agaricus Bisporus

Plants with evidence-based therapeutic effects against neurodegenerative diseases

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