Improving Cardiovascular Outcomes: The Era of Personalized Therapy in Atherosclerosis

Kabłak‐Ziembicka, Anna

doi:10.3390/jcm11113077

Cited by 2 publications

(3 citation statements)

References 22 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In elderly patients, the following are observed more often: inferior wound healing, bleeding and thromboembolic events, renal complications, a more difficult return to daily activities, deterioration of cognitive functions and dementia, presence of chronic diseases, and frailty syndrome. All of these factors increase the risk associated with interventional procedures as well as complications in the post-operative period [ 73 , 74 , 75 , 76 , 77 ].…”

Section: The Faces Of Atherosclerosismentioning

confidence: 99%

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review: Part I—Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients

Piechocki,

Przewłocki,

Pieniążek

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

Atherosclerosis is a generalized and progressive disease. Ageing is a key risk factor for atherosclerosis progression that is associated with the increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity and quality of life, and it is associated with reduced life expectancy. Although there is evidence on coronary artery disease management in the elderly, there is insufficient data on the management in older patients presented with atherosclerotic lesions outside the coronary territory. Despite this, trials and observational studies systematically exclude older patients, particularly those with severe comorbidities, physical or cognitive dysfunctions, frailty, or residence in a nursing home. This results in serious critical gaps in knowledge and a lack of guidance on the appropriate medical treatment and referral for endovascular or surgical interventions. Therefore, we attempted to gather data on the prevalence, risk factors, and management strategies in patients with extra-coronary atherosclerotic lesions.

show abstract

Section: The Faces Of Atherosclerosismentioning

confidence: 99%

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review: Part I—Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients

Piechocki,

Przewłocki,

Pieniążek

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…Halting the progression of atherosclerotic lesions is the best indicator of treatment effectiveness [ 27 , 28 , 29 , 30 , 31 ]. Statins, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and calcium channel antagonists (amlodipine) have all been shown to slow the growth of atherosclerotic lesions [ 32 , 33 , 34 , 35 , 36 ].…”

Section: Pharmacological Interventions That Decelerate or Cause Regre...mentioning

confidence: 99%

“…The risk of bleeding is even greater in the elderly. Studies have shown that even low doses of rivaroxaban have a stronger anticoagulant effect in elderly patients (median age 83 (75-87) years) compared to younger patients (median age 30 (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38) years) [108]. This is due to a prolonged prothrombin time, reduced activity of coagulation factors II and X, and reduced thrombin activation.…”

Section: Antiplatelet and Anticoagulant Drugsmentioning

confidence: 99%

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review PART II—Pharmacological Approach for Management of Elderly Patients with Peripheral Atherosclerotic Lesions outside Coronary Territory

Piechocki,

Przewłocki,

Pieniążek

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

Background: Aging is a key risk factor for atherosclerosis progression that is associated with increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity, quality of life, and it is associated with reduced life expectancy. As most multicenter randomized trials exclude elderly and very elderly patients, particularly those with severe comorbidities, physical or cognitive dysfunctions, frailty, or residence in a nursing home, there is insufficient data on the management of older patients presenting with atherosclerotic lesions outside coronary territory. This results in serious critical gaps in knowledge and a lack of guidance on the appropriate medical treatment. In addition, due to a variety of severe comorbidities in the elderly, the average daily number of pills taken by octogenarians exceeds nine. Polypharmacy frequently results in drug therapy problems related to interactions, drug toxicity, falls with injury, delirium, and non-adherence. Therefore, we have attempted to gather data on the medical treatment in patients with extra-cardiac atherosclerotic lesions indicating where there is some evidence of the management in elderly patients and where there are gaps in evidence-based medicine. Public PubMed databases were searched to review existing evidence on the effectiveness of lipid-lowering, antithrombotic, and new glucose-lowering medications in patients with extra-cardiac atherosclerotic occlusive disease.

show abstract

Improving Cardiovascular Outcomes: The Era of Personalized Therapy in Atherosclerosis

Abstract: Data from the European Society of Cardiology report that cardiovascular disease (CVD) is responsible for app [...]

Cited by 2 publications

References 22 publications

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review: Part I—Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review: Part I—Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review PART II—Pharmacological Approach for Management of Elderly Patients with Peripheral Atherosclerotic Lesions outside Coronary Territory

Contact Info

Product

Resources

About