Improving characterization and diagnosis quality of myofascial pain syndrome: a systematic review of the clinical and biomarker overlap with delayed onset muscle soreness

Vadasz, Brian; Gohari, Jacob; West, Daniel W. D.; Grosman‐Rimon, Liza; Wright, Evan; Özçakar, Levent; Srbely, John; Kumbhare, Dinesh

doi:10.23736/s1973-9087.20.05820-7

Cited by 9 publications

(8 citation statements)

References 90 publications

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“…We suppose cfDNA, besides being an inflammatory marker, to be a valuable diagnostic tool due to it fast kinetics and correlation with clinical outcomes. Still, other inflammatory biomarkers ( Vadasz et al, 2020 ) as well as neurotrophic factors ( Mizumura and Taguchi, 2016 ) have been discussed in this regard, which we did not assess.…”

Section: Discussionmentioning

confidence: 97%

Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT

et al. 2021

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Sports-related pain and injury is directly linked to tissue inflammation, thus involving the autonomic nervous system (ANS). In the present experimental study, we disable the sympathetic part of the ANS by applying a stellate ganglion block (SGB) in an experimental model of delayed onset muscle soreness (DOMS) of the biceps muscle. We included 45 healthy participants (female 11, male 34, age 24.16 ± 6.67 years [range 18–53], BMI 23.22 ± 2.09 kg/m2) who were equally randomized to receive either (i) an SGB prior to exercise-induced DOMS (preventive), (ii) sham intervention in addition to DOMS (control/sham), or (iii) SGB after the induction of DOMS (rehabilitative). The aim of the study was to determine whether and to what extent sympathetically maintained pain (SMP) is involved in DOMS processing. Focusing on the muscular area with the greatest eccentric load (biceps distal fifth), a significant time × group interaction on the pressure pain threshold was observed between preventive SGB and sham (p = 0.034). There was a significant effect on pain at motion (p = 0.048), with post hoc statistical difference at 48 h (preventive SGB Δ1.09 ± 0.82 cm VAS vs. sham Δ2.05 ± 1.51 cm VAS; p = 0.04). DOMS mediated an increase in venous cfDNA -as a potential molecular/inflammatory marker of DOMS- within the first 24 h after eccentric exercise (time effect p = 0.018), with a peak at 20 and 60 min. After 60 min, cfDNA levels were significantly decreased comparing preventive SGB to sham (unpaired t-test p = 0.008). At both times, 20 and 60 min, cfDNA significantly correlated with observed changes in PPT. The 20-min increase was more sensitive, as it tended toward significance at 48 h (r = 0.44; p = 0.1) and predicted the early decrease of PPT following preventive stellate blocks at 24 h (r = 0.53; p = 0.04). Our study reveals the broad impact of the ANS on DOMS and exercise-induced pain. For the first time, we have obtained insights into the sympathetic regulation of pain and inflammation following exercise overload. As this study is of a translational pilot character, further research is encouraged to confirm and specify our observations.

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Section: Discussionmentioning

confidence: 97%

Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT

et al. 2021

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“…DOMS is a regional pain syndrome and is a common cause of impaired muscle performance in sports and is associated with reduced muscle strength, edema, muscle soreness, and reduced movement. DOMS is considered an ultrastructural muscle injury and the development of exercise-induced intramuscular edema is seen in relation to DOMS [ 32 - 34 ]. The condition causes tenderness and/or stiffness to palpation and/or movement [ 35 ].…”

Section: Reviewmentioning

confidence: 99%

“…The symptoms are often described as persistent swelling/intramuscular edema, pain, stiffness/soreness to palpation and/or movement, motor weakness, and obstructed range of motion. They often worsen with stimuli such as increased activity and/or palpation [12,16,20,[22][23][24]27,30,[32][33][34][35].…”

Section: Intrafasciomembranal Fluid Pressure As a Unifying Modelmentioning

confidence: 99%

Intrafasciomembranal Fluid Pressure: A Novel Approach to the Etiology of Myalgias

Hopen¹

2022

Cureus

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Fascia is a continuous membrane (fasciomembrane) that enables differentiation of fluid pressure on either side. Fascia membrane also enables an internal increased fluid pressure at all muscle levels (fibers, fiber bundles, skeletal muscles, compartments), and the author introduces a new unifying term for these pressures, regardless of the anatomical level - the intrafasciomembranal fluid pressure (IFMFP). Swelling, pain, and loss of tissue function are identified as common cardinal symptoms in trigger point (TrP), chronic exertional compartment syndrome (CECS), overtraining syndrome (OTS), and delayed onset muscle soreness (DOMS). Existing literature and an overall assessment indicate that intramuscular conditions related to fluid flow and pressure play a central role in different conditions, providing a common biomechanical explanation of the etiology and influence, supporting the article's theory that an increased IFMFP plays a key role in these conditions.

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“…In scientific articles, these two terms are sometimes used incorrectly as equivalent to each other. Sometimes this similarity leads to misdiagnosis and consequent treatment failure [9,10] .…”

Section: Tender Pointsmentioning

confidence: 99%

Trigger and Tender Points (Definitions, Similarities, Differences, Treatments)

Motaqi

Ghanjal

2020

IJMPP

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Improving characterization and diagnosis quality of myofascial pain syndrome: a systematic review of the clinical and biomarker overlap with delayed onset muscle soreness

Cited by 9 publications

References 90 publications

Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT

Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT

Intrafasciomembranal Fluid Pressure: A Novel Approach to the Etiology of Myalgias

Trigger and Tender Points (Definitions, Similarities, Differences, Treatments)

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