Improving Clinical Practice: Should We Give Influenza Vaccinations to Heart Transplant Patients?

White‐Williams, Connie; Brown, Robert N.; Kirklin, John W.; Clair, K. St.; Keck, Sally; O’Donnell, J. R.; Pitts, Douglas E.; Bakel, Adrian Van

doi:10.1016/j.healun.2005.09.015

Cited by 37 publications

(20 citation statements)

References 7 publications

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“…Figure S1). In a single patient (1.6%) (10,26,(29)(30)(31)(32)(33). Furthermore, our data confirm and extend the results of the single study which analyzed postvaccinal HLA antibodies and showed that in heart transplant recipients no significant donor-specific allosensitization was induced by influenza vaccination (30).…”

Section: Anti-influenza Antibodiessupporting

confidence: 85%

Humoral and Cellular Immune Responses after Influenza Vaccination in Kidney Transplant Recipients

Candon

Thervet

Lebon

et al. 2009

American Journal of Transplantation

109

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Section: Anti-influenza Antibodiessupporting

confidence: 85%

Humoral and Cellular Immune Responses after Influenza Vaccination in Kidney Transplant Recipients

Candon

Thervet

Lebon

et al. 2009

American Journal of Transplantation

109

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“…6 Indeed rate of rejections did not increase in the months before, during, or after the administration of the influenza vaccine. 11 Another reason of missing vaccination was impaired state of health similarly to other studies conducted in the same area. 18,19 Among SOT recipients this belief can be attributed to the immunosuppressive therapy.…”

Section: Discussionmentioning

confidence: 75%

“…Because successful vaccination requires a partial activation of the immune system, doubts have been raised about a possible increase in the risk of acute rejection episodes, and thus about the safety of influenza vaccination in transplant patients. 11 This fear, however, has not been substantiated by scientific evidence. 6 Indeed rate of rejections did not increase in the months before, during, or after the administration of the influenza vaccine.…”

Section: Discussionmentioning

confidence: 99%

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Determinants of influenza vaccination among solid organ transplant recipients attending Sicilian reference center

Restivo

Vizzini

Mularoni

et al. 2016

Human Vaccines & Immunotherapeutics

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Among solid organ transplant recipients, influenza infection is commonly associated with higher morbidity and mortality than immunocompetent hosts. Therefore, in these subjects influenza vaccination is of paramount importance. The main objective of the study was to assess compliance to vaccination and analyze factors associated with influenza vaccination of solid organ transplant recipients admitted to the Sicilian solid organ transplant Reference Center IRCCS-ISMETT in Palermo during 2014-2015 influenza season. Thirty one (37.8%) out of 82 solid organ transplant recipients were vaccinated against influenza. The main reason for vaccination refusal was fear of adverse reaction (n D 16, 31.4%), impaired health status (n D 14, 27.4%) and low vaccine efficacy (n D 10, 19.6%). Vaccinated solid organ transplant recipients compare with unvaccinated had smaller hospital admissions for infectious respiratory diseases (9.7% Vs 23.5%) during surveillance period. On multivariate analysis the factors positively associated with influenza vaccination were the advice of Reference Center physicians (OR 53.4, p < 0.001) and to perform vaccine against pneumococcus (OR 7.0, p D 0.016). This study showed that Reference Center physicians play a key role on vaccine communication and recommendation for patients at risk and it underlines the effectiveness of influenza vaccination in solid organ transplant recipients. However, it remains that, although physician advice resulted a strong determinant for vaccination, influenza vaccination coverage in this subset of population remains still unsatisfactory.

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“…With seasonal influenza vaccine, there has been anecdotal concern for vaccine‐triggered allograft rejection 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine

Quintana

Serra

Molina-Llauradó

et al. 2012

Influenza Resp Viruses

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Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background Patients with end‐stage renal disease have a reduced response to vaccination because of the general suppression of the immune system associated with uraemia. Objectives We evaluated the immune response and differential factors in the immunogenecity to an adjuvanted A(H1N1) pdm09 vaccine (Pandemrix®) in four populations of renal patients after one and two doses of vaccine. Patients Methods 151 patients were included in this study: 58 chronic haemodialysis patients, 52 renal allograft recipients, 14 peritoneal dialysis patients and 27 patients with advanced chronic kidney disease in preparation for kidney replacement therapy. Influenza‐specific antibody levels were measured by monitoring A(H1N1) pdm09 titres using a haemagglutination inhibition assay. Results The seroconversion rate at 42 days after two vaccine doses was 80% in the haemodialysis group, 64·9% in the renal allograft recipients group, 100% in the advanced chronic kidney disease group and 71·4% in the peritoneal dialysis group (P = 0·041). Conclusions Immune response to two doses of the influenza A H1N1 vaccine is dissimilar in the four renal conditions, confirming that seroprotection in pre‐dialysis, haemodialysis and peritoneal dialysis is similar to that in the general population vaccinated with one dose. In contrast, renal transplant recipients with good allograft function showed inadequate protection and triple immunosuppressive therapy including calcineurin inhibitors, mycophenolate and steroids negatively influenced seroconversion after vaccination in renal recipients.

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Improving Clinical Practice: Should We Give Influenza Vaccinations to Heart Transplant Patients?

Cited by 37 publications

References 7 publications

Humoral and Cellular Immune Responses after Influenza Vaccination in Kidney Transplant Recipients

Humoral and Cellular Immune Responses after Influenza Vaccination in Kidney Transplant Recipients

Determinants of influenza vaccination among solid organ transplant recipients attending Sicilian reference center

Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine

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