Predicting the trajectories of neighboring vehicles is essential to evade or mitigate collision with traffic participants. However, due to inadequate previous information and the uncertainty in future driving maneuvers, trajectory prediction is a difficult task. Recently, trajectory prediction models using deep learning have been addressed to solve this problem. In this study, a method of early warning is presented using fuzzy comprehensive evaluation technique, which evaluates the danger degree of the target by comprehensively analyzing the target’s position, horizontal and vertical distance, speed of the vehicle, and the time of the collision. Because of the high false alarm rate in the early warning systems, an early warning activation area is established in the system, and the target state judgment module is triggered only when the target enters the activation area. This strategy improves the accuracy of early warning, reduces the false alarm rate, and also speeds up the operation of the early warning system. The proposed system can issue early warning prompt information to the driver in time and avoid collision accidents with accuracy up to 96%. The experimental results show that the proposed trajectory prediction method can significantly improve the vehicle network collision detection and early warning system.