“…Based on the theory of positive differential systems [5], this robust state estimation technique is of particular interest for bioprocesses, which suffer from high uncertainties (on the inputs, measurements and model dynamics) and the lack of on-line measurements. Interval observers have been successfully applied to biological systems [6,7,8,9], chaotic dynamics [10,11], linear systems with additive disturbances [12], linear parameter-varying systems [13], etc. Assuming that a guaranteed bound of the initial unknown state and bounds on the uncertainties (inputs, disturbances, parameters, ...) are provided, a framer basically consists in an auxiliary dynamical system whose trajectories always stay above or below (component by component) those of the original system.…”