Improving control over the impulse for reward: Sensitivity of harmful alcohol drinkers to delayed reward but not immediate punishment

Rossiter, Sarah; Thompson, Julian; Hester, Robert

doi:10.1016/j.drugalcdep.2012.03.017

Cited by 26 publications

(21 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That impulsivity may moderate present results is noted in the Introduction. Impulsivity is considered a prominent feature of AUD (Dick et al, ; Kumar et al, ) and is associated with higher reward sensitivity and deficits in behavioral inhibition (Rossiter, Thompson, & Hester, ). As expected, impulsivity was highly correlated with AUD in the present study.…”

Section: Discussionmentioning

confidence: 99%

Decision‐ and feedback‐related brain potentials reveal risk processing mechanisms in patients with alcohol use disorder

et al. 2019

View full text Add to dashboard Cite

Individuals with alcohol use disorder (AUD) are aware of the risks of alcohol abuse yet continue risky drinking. Research indicates that dysfunctional decision processes and trait variables such as impulsivity contribute to this awareness‐behavior discrepancy. The present study focused on decision‐related versus feedback‐related processes as potential contributors to decision making in AUD by examining the relationship between decision choices and decision‐ and feedback‐related ERP phenomena in the balloon analogue risk task (BART). N = 39 AUD and n = 35 healthy comparison participants (HC) performed the BART modified for EEG assessment. In each of 100 runs, participants made a series of choices about whether to pump up a virtual balloon, which popped pseudorandomly, ending the run. Alternatively, participants ended the run by pressing a “cash‐out” button. Each pump not producing a pop provided .05 €; popping resulted in loss of the run’s accumulated gain. Groups made similar choices, though AUD responded more slowly. The decision P3 200‒400 ms after decision prompt (balloon) was larger in AUD than in HC, and decision P3 enhancement on high‐risk trials predicted choices to pump. Feedback‐related negativity (FRN) after loss (relative to cash out) feedback was smaller in AUD than in HC, suggesting indifference to negative feedback. In AUD, high impulsivity was associated with risk‐modulated decision P3 but not FRN. Results indicate atypical decision‐ and feedback‐related processes that could contribute to difficulties in engaging with daily challenges effectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Decision‐ and feedback‐related brain potentials reveal risk processing mechanisms in patients with alcohol use disorder

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Third, inhibitory control is a multidimensional construct that cannot be fully characterized by behavioral tasks that solely address motor response inhibition. Thus, paradigms that examine delay discounting, risky decision making, reward responsivity would need to be considered to understand the multifaceted etiologies of alcohol misuse (Moreno et al, 2012; Rossiter et al, 2012). Fourth, the SST is widely used to probe cognitive control, but the SSRT as a measure of inhibitory control appears to be noisy and not as robust when compared to the neural responses to inhibitory control.…”

Section: Discussionmentioning

confidence: 99%

Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers

Zhang

Chao

et al. 2016

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background Deficits in inhibitory control have been widely implicated in alcohol misuse. However, the literature does not readily distinguish the effects of drinking problems and chronic alcohol use. Here, we examined how years of drinking and the Alcohol Use Disorders Identification Test (AUDIT) score each influences the cerebral responses to inhibitory control in non-dependent drinkers. Methods Fifty-seven adult drinkers and 57 age and gender matched non-drinkers participated in one 40-minute fMRI scan of the stop signal task. Data were pre-processed and modeled using SPM8. In a regression model, we contrasted stop and go success trials for individuals and examined activities of response inhibition each in link with the AUDIT score and years of alcohol use in group analyses. We specified the effects of duration of use by contrasting regional activations of drinkers and age-related changes in non-drinkers. In mediation analyses, we investigated how regional activities mediate the relationship between drinking problems and response inhibition. Results Higher AUDIT score but not years of drinking was positively correlated with prolonged stop signal reaction time (SSRT) and diminished responses in the cerebellum, thalamus, frontal and parietal regions, independent of years of alcohol use. Further, activity of the thalamus, anterior cingulate cortex, and pre-supplementary motor area significantly mediates the association, bidirectionally, between the AUDIT score and SSRT. The duration of alcohol use was associated with decreased activation in the right inferior frontal gyrus extending to superior temporal gyrus, which was not observed for age-related changes in non-drinkers. Conclusions The results distinguished the association of drinking problems and years of alcohol use to inhibitory control in young adult non-dependent drinkers. These new findings extend the imaging literature of alcohol misuse and may have implications for treatment to prevent the escalation from social to dependent drinking. More research is needed to confirm age-independent neural correlates of years of alcohol use.

show abstract

“…Furthermore, recent research suggests that these mechanisms may act differently in the case of substance use disorder (Parvaz et al, 2015, Paulus et al, 2008, Rossiter et al, 2012). The mechanisms responsible for processing punishments may be of particular interest in understanding maladaptive decision-making in alcohol use disorder because aversive consequences of alcohol use seem to be often consciously acknowledged but behaviorally ignored by abusers.…”

Section: Introduction1mentioning

confidence: 99%

Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence

Beylergil

Beck

Deserno

et al. 2017

NeuroImage: Clinical

View full text Add to dashboard Cite

Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the “double-update” model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.

show abstract

Improving control over the impulse for reward: Sensitivity of harmful alcohol drinkers to delayed reward but not immediate punishment

Cited by 26 publications

References 57 publications

Decision‐ and feedback‐related brain potentials reveal risk processing mechanisms in patients with alcohol use disorder

Decision‐ and feedback‐related brain potentials reveal risk processing mechanisms in patients with alcohol use disorder

Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers

Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence

Contact Info

Product

Resources

About