Objective. This study examines whether patient-reported indicators of a quality medical home are associated with measures of health among Latino children in low-income families. Data Sources. Data on 3,258 children ages 2-18 years are from a cross-sectional survey of parents of children affiliated with California's Healthy Kids insurance. Study Design. Medical home quality was assessed using the Parents' Perception of Primary Care and was associated with health-related quality of life (HRQOL) overall and in four domains (physical, emotional, social, and school/daycare) and four measures of school engagement. Principal Findings. A higher total medical home score was associated with a higher total Pediatric Quality of Life Inventory score and scores in four subdomains (total beta [B] 5 1.77, physical B 5 1.71, social B 5 1.36, emotional B 5 2.22, and school/daycare B 5 1.69, all po0.001). It was also associated with missing fewer than three school days due to illness (odds ratio [OR] Key Words. Primary care, health-related quality of life, access to careThe provision of a medical home for children is now a major focus of pediatric health care practice and policy, and it is promoted in the recent major health care reforms contained in the Patient Protection and Affordable Care Act of 2010. The medical home is an approach to the delivery of primary care that facilitates partnerships between patients and physicians, embraced by most r Health Research and Educational Trust