Improving crossing of multiple bio-delivery barriers by a novel bio-interface design based on hydrophobic nanoparticle surfaces

Dai, Jie; Xu, Zixing; Xu, Jinhua; Lin, Huoyue; Yang, Xuan; Wang, Jun; Ruan, Gang

doi:10.1039/d2tb01919a

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…[47] NPs loaded with anticancer drug, raloxifene, showed higher cellular uptake and enhanced cytotoxicity in various breast cancer cells at lower pH as compared to NPs without targeting peptide. In a similar fashion, RGD peptides were conjugated to lipid NPs, [48] magnetic NPs, [49] hydrophobic SDot NPs, [50] and upconversion NPs [51,52] for biomedical applications.…”

Section: The Iron Oxide Nps Caused Tumor Apoptosis Through Dox Mediat...mentioning

confidence: 99%

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Ilieş,

Yildiz,

Abbas

2024

ChemBioChem

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Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging and biosensing. They can be covalently incorporated into a variety of nanoparticles (NPs) including polymers, metallic nanoparticles, and others. Using different bioconjugation techniques, multifunctional peptide‐modified NPs can be formulated to produce therapeutical and diagnostic platforms offering high specificity, lower toxicity, biocompatibility, and stimuli responsive behavior. Targeting peptides can direct the nanoparticles into specific tissues for targeted drug and gene delivery and imaging applications due to their specificity towards certain receptors. Furthermore, due to their stimuli‐responsive features, they can offer controlled release of therapeutics into desired sites of disease. In addition, peptide‐based biosensors and imaging agents can provide non‐invasive detection and monitoring of diseases including cancer, infectious diseases, and neurological disorders. In this review, we covered the design and formulation of recent peptide‐based NP platforms, as well as their utilization in in vitro and in vivo applications such as targeted drug and gene delivery, targeting, sensing, and imaging applications. In the end, we provided the future outlook to design new peptide conjugated nanomaterials for biomedical applications.

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Section: The Iron Oxide Nps Caused Tumor Apoptosis Through Dox Mediat...mentioning

confidence: 99%

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Ilieş,

Yildiz,

Abbas

2024

ChemBioChem

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“…Specific integrins identify the RGD motif within proteins and bind to this peptide, allowing cell adhesion and communication. RGD peptides have been widely explored for diverse uses in medicine and biotechnology due to their ability to improve cell adhesion and target particular integrin receptors 10,16–19 . To increase cell adhesion and growth, RGD peptides can be introduced into biomaterials such as hydrogels and scaffolds.…”

Section: Introductionmentioning

confidence: 99%

“…RGD peptides have been widely explored for diverse uses in medicine and biotechnology due to their ability to improve cell adhesion and target particular integrin receptors. 10 , 16 , 17 , 18 , 19 To increase cell adhesion and growth, RGD peptides can be introduced into biomaterials such as hydrogels and scaffolds. This may enhance these materials' biocompatibility and efficacy in the regeneration and repair of tissues.…”

Section: Introductionmentioning

confidence: 99%

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

Javid,

Oryani,

Rezagholinejad

et al. 2024

Cancer Medicine

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RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medicine, including incorporation into biomaterials, conjugation to medicinal molecules or nanoparticles, and labeling with imaging agents. RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing adverse effects on healthy tissues. RGD‐functionalized drug carriers are a viable option for cancer therapy as this focused approach has demonstrated promise in the future. Writing a review on the RGD peptide can significantly influence how drugs are developed in the future by improving our understanding of the peptide, finding knowledge gaps, fostering innovation, and making drug design easier.

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Improving crossing of multiple bio-delivery barriers by a novel bio-interface design based on hydrophobic nanoparticle surfaces

Abstract: Biological delivery remains a major challenge in biotechnology, partly because it is often not enough to overcome a single delivery barrier. It is highly desirable, yet rarely available, to design...

Cited by 2 publications

References 36 publications

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

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