Improving cystine stone therapy: an in vitro study of dissolution

Heimbach, D.; Jacobs, D.; Müller, Stefan; Hesse, Albrecht

doi:10.1016/s0090-4295(99)00386-6

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…However, at higher pH, the risk of calcium phosphate calculi formation becomes higher. This problem would be particularly serious if a recent recommendation [33] to use THAM (tris-(hydroxymethylene)-aminomethane) buffer at pH = 10 for in vivo cystine chemolysis were applied. Even at pH ≈ 7, significant HAP precipitation is not only predicted by computer simulations [15] but also observed experimentally [15,34].…”

confidence: 99%

Thermodynamic modeling of crystal deposition in humans

Königsberger

2001

Pure and Applied Chemistry

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Abstract:The prevention and treatment of crystal deposition in the human body are based on the understanding of the physicochemical properties underlying the precipitation of the substances involved. Among these properties, the solubilities of the crystals are very important. Recently, experimentally determined solubility data of substances related to urolithiasis, such as calcium oxalate hydrates, uric acid and urates, cystine, and xanthine, were critically assessed. Unfortunately, reported solubilities of these substances were found to be either scarce or in large disagreement. Consequently, detailed studies were carried out in our laboratory, and the results will be discussed in this communication with emphasis on the thermodynamic consistency of the experimentally determined data. Since proper modeling of the solubilities of these substances in artificial urine solutions serves as a prerequisite for solubility predictions in real urine, the Joint Expert Speciation System (JESS) software package was employed to create a comprehensive computer model including the relevant, low-molecular inorganic and organic components of urine. The results of the simulations lead to some useful suggestions regarding the prevention and treatment of stone disease.

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confidence: 99%

Thermodynamic modeling of crystal deposition in humans

Königsberger

2001

Pure and Applied Chemistry

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“…The structural characterisation of cystine kidney stones has been discussed in several publications. Consistent with its crystallographic structure (hexagonal crystal system, P6 1 22 space group), all the papers on synthetic [47][48][49][50][51][52][53][54] or biological [18][19][20][21]24,55,56,[64][65][66] cystine have reported a hexagonal morphology. On SEM observations, at the micrometre scale, we can clearly see the hexagonal shape of the cystine deposits in kidney stones from mice and humans affected by cystinuria (Figure 2).…”

Section: The Case Of Cystinuriamentioning

confidence: 69%

“…The literature clearly indicates the presence of rectangular crystals made of cystine [29][30][31][71][72][73][74][75][76][77][78][79]81]. Such morphology is not expected for cystine crystals which are typically hexagonal for synthetic [47][48][49][50][51][52][53][54] as well as for biological [18][19][20][21]24,55,56,[64][65][66] samples. Rectangular-like crystallites are observed in the case of synthetic cysteine (Figure 5c).…”

Section: Discussionmentioning

confidence: 99%

“…To do this, we undertook a structural and spectroscopic analysis of such abnormal deposits using scanning electron microscopy (SEM) [14,39,40], µFTIR (Fourier Transform InfraRed) [14,41,42], AFM-IR (atomic force microscopy coupled with IR) spectroscopy [43,44] and OPTIR (Optical Photothermal IR) spectroscopy [45,46]. SEM offers the opportunity to directly observe the morphology and size of crystallites at the micrometre scale and contributes significantly to the structural description of cystine crystals (see for examples [47][48][49][50][51][52][53][54]). µFTIR spectroscopy constitutes the gold standard for precisely determining the chemical composition of kidney stones [41,42,55,56].…”

Section: Introductionmentioning

confidence: 99%

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Cystinuria and cystinosis are usually related to L-cystine: is this really the case for cystinosis? A physicochemical investigation at micrometre and nanometre scale

Bazin¹,

Rabant²,

Mathurin³

et al. 2022

Comptes Rendus. Chimie

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“…Dissolution of crystals are among the most common interventions for the treatment of nephrolithiasis . Several studies have investigated the efficacy of dissolution therapies for different types of stones, including cysteine, struvite, and uric acid stones, all of which are found in kidney stones. ,, These therapies include dietary modifications which include encouraging individuals to drink more water than they normally do or through medications. ,, Recently, citrates have been used as dissolution agents for calcium crystals with the added aim of reducing calcium stone recurrence . Similarly, several studies have shown citrates to be more effective in dissolution of calcium crystals, compared to other dissolution agents, such as water alone and phosphates. , Nonetheless, it is most interesting to note that the recurrence rate among individuals who have received some form of intervention or treatment remains as high as 40%. ,, These recurrence rates suggest that current conventional therapies are not that effective.…”

Section: Introductionmentioning

confidence: 99%

Matting Calcium Crystals by Melamine Improves Stabilization and Prevents Dissolution

Boadi

Deems

Raub

et al. 2019

Crystal Growth & Design

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Melamine induces calcium phosphate (CaP) and calcium oxalate (CaOx) crystal formation; however, the physicochemical mechanism is not clear. Recently, we found that melamine has a discriminatory effect on CaP, CaOx, and CaP + CaOx (Mixed) crystal dissolution. Thus, to delineate the mechanism, we examined crystal interactions through birefringence analysis and found that CaP becomes increasingly birefringent when bound to melamine, while the birefringence of CaOx decreases when it forms CaOx−melamine cocrystals. We also confirmed the feasibility of such melamine− CaP/CaOx co-crystallization at the nanomicromolar range. Interestingly, ammeline, which is a similar triazine, did not accelerate CaP/CaOx/Mixed crystal formation and growth, indicating the specificity of crystal interaction by melamine. Furthermore, melamine stabilizes the CaP/CaOx/Mixed crystals when exposed to a crystal inhibitor (etidronic acid) or dissolution agents (citrate analogues), while it induces crystal growth by increasing crystal retention, suggesting melamine's interference with conventional dissolution remedies. Morphological and elemental analysis of melamine−CaP/CaOx/ Mixed co-crystals using scanning electron microscopy further revealed that melamine harbors such crystals by creating a nucleation site. Finally, we confirmed the physiological relevance of melamine exposure using artificial urine to show the induction, stabilization, and retention of mixed crystals in the presence of crystal-inhibitor/dissolution agent and thus established potential causes of recurrence of kidney stones.

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Improving cystine stone therapy: an in vitro study of dissolution

Cited by 13 publications

References 18 publications

Thermodynamic modeling of crystal deposition in humans

Thermodynamic modeling of crystal deposition in humans

Cystinuria and cystinosis are usually related to L-cystine: is this really the case for cystinosis? A physicochemical investigation at micrometre and nanometre scale

Matting Calcium Crystals by Melamine Improves Stabilization and Prevents Dissolution

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