Background: Two core dual processing theory (DPT) System I constructs (Exemplars and Prototypes) were used to: 1) formulate a training exercise designed to improve diagnostic performance in year one medical students, and 2) explore whether any observed performance improvements were associated with preferential use of exemplars or prototypes. Methods: With IRB approval, 117 year one medical students participated in an acute chest pain diagnostic training exercise. A pre-and post-training test containing the same 27 case vignettes was used to determine if the subjects' diagnostic performance improved via training in both exemplars and prototypes. Exemplar and Prototype theory was also used to generate a unique typicality estimate for each case vignette. Because these estimates produce different performance predictions, differences in the subjects' observed performance would make it possible to infer whether subjects were preferentially using Exemplars or Prototypes. Results: Pre-vs. post-training comparison revealed a significant performance improvement; t = 14.04, p < 0.001, Cohen's d = 1.32. Pre-training, paired t-testing demonstrated that performance against the most typical vignettes > mid typical vignettes: t = 4.94, p < 0.001; and mid typical > least typical: t = 5.16, p < 0.001. Post-training, paired t-testing again demonstrated that performance against the most