Improving Dispersal of Therapeutic Nanoparticles in The Human Body

Limongi, Tania; Canta, Marta; Racca, Luisa; Ancona, Andrea; Tritta, Stefania; Vighetto, Veronica; Cauda, Valentina

doi:10.2217/nnm-2019-0070

Cited by 33 publications

(26 citation statements)

References 20 publications

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“…An additional enhancement could be generated by improving the colloidal dispersibility of ZnO NCs (Dumontel et al, 2019;Limongi et al, 2019). These interesting features could be successfully exploited for a future application of ZnO NCs and SW in in vivo investigations and clinic.…”

Section: Future Overviewmentioning

confidence: 99%

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Racca

Limongi

Vighetto

et al. 2020

Front. Bioeng. Biotechnol.

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In the last years, different nanotools have been developed to fight cancer cells. They could be administered alone, exploiting their intrinsic toxicity, or remotely activated to achieve cell death. In the latter case, ultrasound (US) has been recently proposed to stimulate some nanomaterials because of the US outstanding property of deep tissue penetration and the possibility of focusing. In this study, for the first time, we report on the highly efficient killing capability of amino-propyl functionalized ZnO nanocrystals (ZnO NCs) in synergy with high-energy ultrasound shock waves (SW) for the treatment of cancer cells. The cytotoxicity and internalization of ZnO NCs were evaluated in cervical adenocarcinoma KB cells, as well as the safety of the SW treatment alone. Then, the remarkably high cytotoxic combination of ZnO NCs and SW was demonstrated, comparing the effect of multiple (3 times/day) SW treatments toward a single one, highlighting that multiple treatments are necessary to achieve efficient cell death. At last, preliminary tests to understand the mechanism of the observed synergistic effect were carried out, correlating the nanomaterial surface chemistry to the specific type of stimulus used. The obtained results can thus pave the way for a novel nanomedicine treatment, based on the synergistic effect of nanocrystals combined with highly intense mechanical pressure waves, offering high efficiency, deep and focused tissue penetration, and a reduction of side effects on healthy cells.

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Section: Future Overviewmentioning

confidence: 99%

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Racca

Limongi

Vighetto

et al. 2020

Front. Bioeng. Biotechnol.

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“…The main purposes of these modifications are to increase the NPs biocompatibility and colloidal stability, enhancing at the same time their properties, e.g., their efficiency of heating. Silica [12,69], gold [70], copper, palladium, and other metals have been extensively investigated as NPs inorganic shielding [65,71]. The coating with gold is particularly attractive because the gold layer improves the chemical stability and biocompatibility of the magnetic NPs.…”

Section: Magnetic Npsmentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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“…Considering the various types of materials that can be loaded into the vesicles with the techniques described above, we can assert that NPs can be finely tuned for a wide number of applications through a strict control of physical and chemical parameters [112]. However, when administered into the body, they could face some problems such as opsonization and/or aggregation [113,114].…”

Section: Loading Nanotechnological Modification Into Evsmentioning

confidence: 99%

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Susa

Limongi

Dumontel

et al. 2019

Cancers

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Fast diagnosis and more efficient therapies for cancer surely represent one of the huge tasks for the worldwide researchers’ and clinicians’ community. In the last two decades, our understanding of the biology and molecular pathology of cancer mechanisms, coupled with the continuous development of the material science and technological compounds, have successfully improved nanomedicine applications in oncology. This review argues on nanomedicine application of engineered extracellular vesicles (EVs) in oncology. All the most innovative processes of EVs engineering are discussed together with the related degree of applicability for each one of them in cancer nanomedicines.

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Improving Dispersal of Therapeutic Nanoparticles in The Human Body

Abstract: in vivo tests • lipid bilayers • organic coating • protein corona • stealth nanoparticles • thrombogenicity Nanomedicine (Lond.

Cited by 33 publications

References 20 publications

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Remotely Activated Nanoparticles for Anticancer Therapy

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

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