Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats

Shibata, Shigenobu; Kodama, Kohtaroh; Koga, Yoshiko; Ueki, Showa; Watanabe, Soichi

doi:10.1016/0006-8993(93)91244-m

Cited by 12 publications

(1 citation statement)

References 53 publications

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“…The beneficial effect of H. rhamnoides on brain may also be attributed to various non-antioxidant mechanisms like increased glucose uptake in the brain. 49 There was a small but significant increase in kidney arsenic concentration after the administration of HF-EtOH, which could be attributed to the fact that the route of arsenic elimination is through the kidneys, and in the case H. rhamnoides extract the arsenic may have been metabolized, and the ethanol, which also acts as a good diuretic, may have placed an extra load on the kidneys.…”

Section: Figmentioning

confidence: 95%

Therapeutic Value ofHippophae rhamnoidesL. Against Subchronic Arsenic Toxicity in Mice

Gupta

Flora

2005

Journal of Medicinal Food

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The present study was planned to investigate the therapeutic efficacy of Hippophae rhamnoides L. against the toxic effects of arsenic in mice. H. rhamnoides L. is used as an herbal remedy for gastric ulcers, burns, and some skin and allergic diseases. Twenty-five Swiss albino mice were exposed to arsenic (25 ppm) in drinking water for 3 months. After 3 months different fruit extracts of H. rhamnoides L. (500 mg/kg for 10 days) were administered, the animals were sacrificed, and blood and tissues were assayed for various biochemical indicators of oxidative stress and whether arsenic was removed from tissues. Treatment with different fruit extracts of H. rhamnoides L. showed significant protection from arsenic inhibition of blood delta-aminolevulinic acid dehydratase activity and restored blood reduced glutathione levels. Other hematologic variables like white blood cell counts, hemoglobin, and hematocrit were partially protected by supplementation with a water extract of H. rhamnoides L. (HF-WRT). Significant protection was also observed in altered hepatic, renal, and brain reduced/ oxidized glutathione ratio and thiobarbituric acid-reactive substances levels. The aqueous extract of H. rhamnoides L. (HF-WRT) also provided protection against parameters indicative of liver injury such as aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities. There was also no effect on blood and tissue arsenic concentrations observed except some moderate depletion of blood arsenic concentrations, suggesting that the drug has no ability to chelate intracellular arsenic. It can be concluded from these results that post-treatment with an aqueous extract of H. rhamnoides L. (HF-WRT) significantly protects against arsenic-induced oxidative stress but does not chelate arsenic, suggesting it may have a beneficial role as a supplementing agent during chelation of arsenic by other means.

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Section: Figmentioning

confidence: 95%

Therapeutic Value ofHippophae rhamnoidesL. Against Subchronic Arsenic Toxicity in Mice

Gupta

Flora

2005

Journal of Medicinal Food

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Chronic nicotine treatment prevents neuronal loss in neocortex resulting from nucleus basalis lesions in young adult and aged rats

Socci

Arendash

1996

Molecular and Chemical Neuropathology

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In both young adult and aged rats, we tested the ability of chronically administered nicotine to rescue neocortical neurons from transneuronal degeneration resulting 5 mo after ibotenic acid (IBO) lesioning of the nucleus basalis magnocellularis (NBM). Young adult (2-3 mo-old) and aged (20-22-mo-old) rats were given unilateral infusions of IBO (5 mu g/1 mu L) at two sites within the NBM. Following surgery, animals began receiving either daily ip injections of nicotine (0.2 mg/kg) or saline vehicle. Treatment continued for 5 mo, at which time all animals were sacrificed and their brains processed histologically. For each brain, computer-assisted image analysis was then used to analyze the unlesioned (left) and lesioned (right) side of five non-consecutive brain sections from parietal cortex Layers II-IV and V. NBM lesioning in both young adult and aged vehicle-treated rats resulted in a significant 16-21% neuronal loss ipsilateral to NBM lesioning in neocortical Layers II-IV. Aged NBM-lesioned rats also exhibited a significant 12% neuronal loss in neocortical Layer V ipsilaterally. By contrast, those NBM-lesioned young adult and aged rats that received daily nicotine treatment postsurgery did not show any ipsilateral neuronal loss in the same parietal cortex areas, indicating that chronic nicotine treatment prevented the transneuronal degeneration of neocortical neurons resulting 5 mo afer NBM lesioning.

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Facilitatory effect of olfactory bulbectomy on 2-deoxyglucose uptake in rat amygdala slices

Shibata¹,

Watanabe²

1994

Brain Research

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Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats

Cited by 12 publications

References 53 publications

Therapeutic Value ofHippophae rhamnoidesL. Against Subchronic Arsenic Toxicity in Mice

Therapeutic Value ofHippophae rhamnoidesL. Against Subchronic Arsenic Toxicity in Mice

Chronic nicotine treatment prevents neuronal loss in neocortex resulting from nucleus basalis lesions in young adult and aged rats

Facilitatory effect of olfactory bulbectomy on 2-deoxyglucose uptake in rat amygdala slices

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