The needs of the English language had been changed along with the increased demand of graduates in facing the Industry 4.0 which also implied that speaking skills became the key for the graduates to communicate with people from various backgrounds. This research aimed to investigate the factors influencing the speaking fluency of the students in English in Focus course to find out the proper teaching-learning method in speaking session. The case-study method was implemented to conclude this research. The participants of this study were 127 students majoring in Information System & Management Program, Accountancy Program, Japanese Department, and International Relation Department who registered in English in Focus Course in the odd semester, 2018/2019 academic year. The data were gathered through equestionnaire, depth analysis on students' speaking recording tasks, and document analysis. The result showed nine factors were affecting the speaking fluency in English.