Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol

Meng, Lingwei; Chu, Xiaoyang; Xing, Haoyue; Li, Xuan; Xin, Xin; Chen, Liqing; Jin, Mingji; Guan, Youyan; Huang, Wei; Gao, Zhonggao

doi:10.1016/j.ijpharm.2019.118485

Cited by 45 publications

(31 citation statements)

References 48 publications

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“…The borneol combination could further enhance the anti-tumour efficiency of multiple drug targeting systems after penetrating the BBB. These effects were observed with a borneol-modified nanomicelle delivery system with doxorubicin for glioblastoma therapy in vitro and in vivo [254]. Similar effects were obtained using PEG-PAMAM nanoparticles co-loaded with paclitaxel and borneol in ovarian cancer cells [255].…”

Section: Borneolsupporting

confidence: 64%

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Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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Section: Borneolsupporting

confidence: 64%

“…Enhanced doxorubicin delivery in vitro and in vivo using borneol modified nanomicelles [254]. Enhanced chemotherapeutic effects when loaded in nanomolecule formulations [255][256][257][258].…”

Section: Increased Doxorubicin-induced Interference Withmentioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

View full text Add to dashboard Cite

show abstract

“…Among these different nanocarriers, polymers have met the strict requirements required for biological applications. For instance, Meng et al found that a borneol-modified nanomicelle loaded with DOX exhibited superior transport efficiency of DOX across the BBB and accumulation in the brain tissues [ 131 ]. Likewise, a study suggested the usage of positively charged chitosan-coated pegylated NPs for co-delivery of R-flurbiprofen and PTX to glioma tissue.…”

Section: Application and Clinical Trials Of Nanocarrier-based Thermentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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“…Borneol (Bor) is widely used in traditional Chinese medicine, which can assist other drugs enter the brain. Studies have reported that Bor could open the intercellular tight junctions and improve the permeation of drugs across the BBB, therefore enhance their concentration in the brain (Guo et al, 2019;Meng et al, 2019). However, there is a great risk for anti-glioma drugs because they will cause serious side effects to normal brain tissue due to lacking of active targeting ability (Han et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Anti-Glioma Efficacy by Borneol Combined With CGKRK-Modified Paclitaxel Self-Assembled Redox-Sensitive Nanoparticles

Qian

et al. 2020

Front. Pharmacol.

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The serious therapeutic obstacles to glioma treatment include poor penetration across the blood-brain barrier (BBB) and low accumulation of therapeutic drugs at tumor sites. In this study, borneol combined with CGKRK peptide (a ligand of the heparan sulfate which overexpress on the glioma cells) modified paclitaxel prodrug self-assembled redoxresponsive nanoparticles (CGKRK-PSNPs) were hypothesized to enhance the BBB penetration ability and active tumor targeting efficiency, respectively. The resulting CGKRK-PSNPs possessed a spherical shape with a small particle size (105.61 ± 1.53 nm) and high drug loading for PTX (54.18 ± 1.13%). The drug release behavior proved that CGKRK-PSNPs were highly sensitive to glutathione (GSH) redox environment. The in vitro cell experiments suggested that CGKRK-PSNPs significantly increased the cellular uptake and cytotoxicity of U87MG cells, meanwhile CGKRK-PSNPs showed the low cytotoxicity against BCEC cells. Combined with borneol, CGKRK-PSNPs exhibited enhanced transportation across in vitro BBB model. In intracranial U87MG glioma-bearing nude mice, the higher accumulation of CGKRK-PSNPs combined with borneol was observed through real-time fluorescence image. Moreover, the in vivo anti-glioma results confirmed that CGKRK-PSNPs combined with borneol could improve the anti-glioma efficacy with the prolonged medium survival time (39 days). In conclusion, the collaborative strategy of CGKRK-PSNPs combined with borneol provided a promising drug delivery routine for glioblastoma therapy.

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Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol

Cited by 45 publications

References 48 publications

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Enhanced Anti-Glioma Efficacy by Borneol Combined With CGKRK-Modified Paclitaxel Self-Assembled Redox-Sensitive Nanoparticles

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