Improving Health-Related Quality of Life in Single-Sided Deafness: A Systematic Review and Meta-Analysis

Kitterick, Pádraig T.; Lucas, Laura; Smith, Stephen L.

doi:10.1159/000380753

Cited by 45 publications

(39 citation statements)

References 47 publications

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“…Disease-specific symptoms of hearing impaired patients that influence HRQoL include tinnitus, vertigo, hyper-/dysacusis, which have been also reported for otosclerosis [ 37 – 39 ]. It is well known, that restoration of hearing using hearing aids has a positive impact on HRQoL [ 40 , 41 ]. In addition, there are multiple studies describing an improvement of HRQoL after hearing restoration with active bone conduction or middle ear implants [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Mapping the ChOLE classification to hearing outcomes and disease-specific health-related quality of life

Weiss

Bächinger

Rrahmani

et al. 2020

Eur Arch Otorhinolaryngol

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Objectives To investigate the association between the “ChOLE” classification, hearing outcomes and disease-specific health-related quality of life (HRQoL). Methods In two tertiary referral centers, patients requiring primary or revision surgery for cholesteatoma were assessed for eligibility. Audiometric assessment was performed pre- and postoperatively. The ChOLE classification was determined intraoperatively and via the preoperative CT scan. HRQoL was assessed pre- and postoperatively using the Zurich Chronic Middle Ear Inventory (ZCMEI-21). Results A total of 87 patients (mean age 45.2 years, SD 16.2) were included in this study. ChOLE stage I cholesteatoma was found in 8 (9%), stage II cholesteatoma was found in 65 (75%), and stage III cholesteatoma was found in 14 (16%) patients. Postoperatively, the mean air–bone gap (0.5, 1, 2, 3 kHz) was significantly smaller than before surgery (14.3 dB vs. 23.0 dB; p = 0.0007). The mean ZCMEI-21 total score significantly decreased after surgery (26.8 vs. 20.7, p = 0.004). No correlation between the ZCMEI-21 total score and both the ChOLE stage and the extent of the cholesteatoma (ChOLE subdivision “Ch”) was found. A trend towards worse HRQoL associated with a poorer status of the ossicular chain (ChOLE subdivision “O”) was observed. The audiometric outcomes were not associated with the extent of the cholesteatoma. The ChOLE subdivision describing the ossicular status showed a strong association with the pre- and postoperative air conduction (AC) thresholds. Further, the ZCMEI-21 total score and its hearing subscore correlated with the AC thresholds. Conclusion The ChOLE classification does not show a clear association with HRQoL measured by the ZCMEI-21. The HRQoL neither seems to be associated with the extent of the disease nor with the ossicular chain status. Yet, surgical therapy significantly improved HRQoL by means of reduced ZCMEI-21 total scores, which were strongly associated with the AC thresholds. Intraoperative assessment of a cholesteatoma using the ChOLE classification and HRQoL complement each other and provide useful information.

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Section: Discussionmentioning

confidence: 99%

Mapping the ChOLE classification to hearing outcomes and disease-specific health-related quality of life

Weiss

Bächinger

Rrahmani

et al. 2020

Eur Arch Otorhinolaryngol

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“…Binaural function depends on the activity of binaural neurons in the central auditory pathways, especially at the levels of the superior olivary complex, the nuclei of the lateral lemniscus, and the inferior colliculus [ 1 ]. Impairment of binaural function, as in cases of single-sided deafness (SSD) or asymmetrical hearing loss (AHL) can negatively impact localization, speech understanding in noise, and quality of life (QoL) [ 2 , 3 ]. The prevalence of SSD is estimated to affect 3–6% of the general population [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cortical reorganization after cochlear implantation for adults with single-sided deafness

et al. 2018

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BackgroundAdults with single sided deafness (SSD) have lost binaural function, which limits sound source localization, speech understanding in noise, and quality of life. For SSD patients, restoration of bilateral auditory input is possible only with a cochlear implant (CI). In this study, cortical auditory evoked potentials (CAEPs) and behavioral performance were measured in left-implanted (SSD-CI-L) and right-implanted (SSD-CI-R) patients before and after cochlear implantation. We hypothesized that improvements in behavioral performance would be accompanied by changes in CAEPs after cochlear implantation.DesignProspective longitudinal study.SettingTertiary referral center.MethodNine right-handed adult SSD CI patients participated in the study. CAEPs were recorded before cochlear implantation and at 6 and 12 months post-implantation. CAEPs were elicited using speech stimuli (/ba/) delivered in sound field at 70 dBA. Global field power (GFP) latency and amplitude were calculated for P1, N1 and P2 peaks at each test session. CAEP were analyzed at frontocentral (Cz) and temporal (P7, P8, T7 and T8) and mastoid electrodes (M1 and M2) contralateral to the CI ear. Behavioral measures (sentence recognition in noise, with and without spatial cues) were collected at the same test sessions as for CAEPs. Speech performance and CAEPs were also measured in a control group of normal-hearing (NH) subjects.ResultsWhile increased N1 amplitude was observed in the scalp potential maps for GFP and Cz for SSD-CI-L patients after implantation, the changes were not statistically significant. Peak CAEP amplitude at electrodes to contralateral to the CI ear increased after cochlear implantation for all SSD-CI patients, but significant increases were observed only for mastoid sites. Peak latencies for some components at temporal and mastoid sites remained significantly longer than for the NH control group, even after cochlear implantation. For SSD-CI-R patients, P2 peak amplitude for baseline GFP and Cz was significantly lower than for the NH control group. A significant improvement for speech understanding in noise was observed at 12 months post-implantation when speech was presented to the CI ear and noise to the non-implanted ear.ConclusionAfter cochlear implantation, speech understanding significantly improved when speech and noise were spatially separated. The increased N1 amplitude for SSD-CI-L patients and the increased bilateral activation for all SSD-CI patients may reflect cortical reorganization and restoration of binaural function after one year of experience with the CI. However, because of the limited number of SSD patients, significant changes in cortical activity after cochlear implantation were often difficult to observe.

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“…In adults with SSD, both these abilities are compromised [10][11][12][13][14] and can lead to functional [15], psychological and social consequences [16,17]. The multi-dimensional burden on overall health is indicated by reductions in health-related quality of life [18] in individuals with a diagnosis of SSD.…”

Section: Introductionmentioning

confidence: 99%

Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey

Katiri

Hall

Buggy

et al. 2020

Trials

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Background: Single-sided deafness (SSD) describes the presence of a unilateral severe to profound sensorineural hearing loss. SSD disrupts spatial hearing and understanding speech in background noise. It has functional, psychological and social consequences. Potential options for rehabilitation include hearing aids and auditory implants. Benefits and harms of these interventions are documented inconsistently in the literature, using a variety of outcomes ranging from tests of speech perception to quality of life questionnaires. It is therefore difficult to compare interventions when rehabilitating SSD. The Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study is an international initiative that aims to develop a minimum set of core outcomes for use in future trials of SSD interventions. Methods/design: The CROSSSD study adopts an international two-round online modified Delphi survey followed by a stakeholder consensus meeting to identify a patient-centred core outcome domain set for SSD based on what is considered critical and important for assessing whether an intervention for SSD has worked. Discussion: The resulting core outcome domain set will act as a minimum standard for reporting in future clinical trials and could have further applications in guiding the use of outcome measures in clinical practice. Standardisation will facilitate comparison of research findings.

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Improving Health-Related Quality of Life in Single-Sided Deafness: A Systematic Review and Meta-Analysis

Cited by 45 publications

References 47 publications

Mapping the ChOLE classification to hearing outcomes and disease-specific health-related quality of life

Mapping the ChOLE classification to hearing outcomes and disease-specific health-related quality of life

Cortical reorganization after cochlear implantation for adults with single-sided deafness

Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey

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