Improving Lipids With Prescription Icosapent Ethyl After Previous Use of Fish Oil Dietary Supplements

Reddy, K. J.; Chowdhury, Sumita

doi:10.2217/fca-2015-0009

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…The 4-g daily dose decreased LDL-C levels by 6.2% ( p = 0.007) and significantly reduced other lipid parameters compared with a light liquid paraffin placebo, including apolipoprotein B (9.3%; p < 0.0001), very low-density lipoprotein cholesterol (VLDL-C) (24.4%; p < 0.0001), lipoprotein-associated phospholipase A2 (19.0%; p < 0.0001), and high-sensitivity CRP (hsCRP) (22.0%; p = 0.0005) [ 112 ]. One study of IPE in statin-intolerant patients suggested it might be potentially effective in this group of patients [ 113 ].…”

Section: Methodsmentioning

confidence: 99%

Management of Statin Intolerance in 2018: Still More Questions Than Answers

Tóth

Patti

Giglio

et al. 2018

Am J Cardiovasc Drugs

151

111

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Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutraceuticals can be considered. This review focuses on the definition of statin intolerance and on the development of clinical and therapeutic strategies for its management, including emerging alternative therapies.

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Section: Methodsmentioning

confidence: 99%

Management of Statin Intolerance in 2018: Still More Questions Than Answers

Tóth

Patti

Giglio

et al. 2018

Am J Cardiovasc Drugs

151

111

View full text Add to dashboard Cite

show abstract

“…The authors emphasized that the benefits demonstrated in their study should not be transferred to all omega-3 preparations, especially dietary supplements, due to the differences between the composition of supplements compared with the preparation used in their study [24]. The literature also shows that 4 g of icosapent ethyl improves the lipid profile in patients with statin intolerance [25]. Many other experts also emphasize that omega-3 fatty acids (of proven quality) may be particularly beneficial for statin-intolerant patients with obesity, diabetes, or metabolic syndrome in whom elevated LDL cholesterol is accompanied by high levels of triglycerides [26].…”

Section: Polyunsaturated Omega-3 Fatty Acidsmentioning

confidence: 95%

Dietary Supplements—For Whom? The Current State of Knowledge about the Health Effects of Selected Supplement Use

Wierzejska

2021

IJERPH

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Dietary supplements are products containing nutrients sold in various medicinal forms, and their widespread use may stem from the conviction that a preparation that looks like a drug must have therapeutic properties. The aim of this scoping review is to present what is known about the effects of using selected dietary supplements in the context of chronic diseases, as well as the risks associated with their use. The literature shows that the taking of vitamin and mineral supplements by healthy people neither lowers their risk of cardiovascular diseases nor prevents the development of malignancies. Many scientific societies recognize that omega-3 fatty acids lower blood triglycerides, but whether taking them prevents heart disease is less clear-cut. Taking weight loss supplements is not an effective method of fighting obesity. Often, some supplements are increasingly sold illegally, which is then also associated with the higher risk that they may be adulterated with banned substances, thus making them even more dangerous and potentially life-threatening. Supplements are necessary in cases of nutrient deficiency; however, even though prescription is not required, their use should be recommended and monitored by a physician.

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The Role of Nutraceuticals in Statin Intolerant Patients

Banach

Patti

Giglio

et al. 2018

Journal of the American College of Cardiology

244

145

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Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment. These nutraceuticals could exert significant lipid-lowering activity and might present multiple non-lipid-lowering actions, including improvement of endothelial dysfunction and arterial stiffness, as well as anti-inflammatory and antioxidative properties. The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.

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Improving Lipids With Prescription Icosapent Ethyl After Previous Use of Fish Oil Dietary Supplements

Cited by 5 publications

References 35 publications

Management of Statin Intolerance in 2018: Still More Questions Than Answers

Management of Statin Intolerance in 2018: Still More Questions Than Answers

Dietary Supplements—For Whom? The Current State of Knowledge about the Health Effects of Selected Supplement Use

The Role of Nutraceuticals in Statin Intolerant Patients

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