Improving Mental Health for the Mother-Infant Dyad by Nutrition and the Maternal Gut Microbiome

Bernabé, Beatriz Peñalver; Tussing‐Humphreys, Lisa; Rackers, Hannah; Welke, Lauren; Mantha, Alina; Kimmel, Mary

doi:10.1016/j.gtc.2019.04.007

Cited by 12 publications

(6 citation statements)

References 88 publications

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“…Among putative mechanisms involved in the association between obesity and perinatal depression (PD), the alteration of hypothalamic-pituitary-adrenal (HPA) axis, observed in both obesity and depression, the increase of circulating glucocorticoids, higher levels of inflammation with related serum markers (including specific cytokines), oxidative stress, microbiome and psychological issues related to the changes of body-images, are widely discussed in the literature [6][7][8]. Pavlik and Rosculet [9], in their updated review of literature, discussed that overall evidences from studies conducted within 2020 have shown that obesity in association with its comorbidity may have a possible impact on the development of perinatal depressive symptoms: they reported findings from 5 studies confirming association between obesity and PD and 2 concluding there may be an impact of obesity on the general outcome of pregnancy but not on depressive maternal symptoms.…”

Section: Introductionmentioning

confidence: 99%

The impact of body mass index on the pregnancy outcomes and risk of perinatal depression: Findings from a multicenter Italian study

et al. 2023

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Background Body Mass Index (BMI) is an informative factor on body fatness which has been associated to higher levels of Perinatal Depression (PD) and complications during pregnancy. We aimed to explore the impact of pre-pregnancy and postnatal BMI on the risk of Perinatal Depression and pregnancy outcomes among women recruited at their third trimester of pregnancy. Methods We report on findings from a large multi-centre study conducted in the South of Italy and involving 1611 women accessing three urban gynaecological departments from July to November 2020. Pregnant women were assessed at their third trimester of pregnancy (T0) and after the childbirth (T1) ;The Edinburgh Postnatal Depression Scale (EPDS) has been employed for the screening of PD over time (T0 and T1) as well as other standardized measures for neuroticism, resilience, and quality of life at baseline. BMI (T0 and T1) and other socio-demographic and clinical characteristics have been collected. Results Over-weight and obesity (higher levels of BMI) were associated with higher risk of PD (higher scores of EPDS), higher neuroticism and poorer subjective psychological well-being among enrolled women. Also, obesity and over-weight were associated with lower education, higher number of physical comorbidities, medical treatments and complications during pregnancy. Conclusions Over-weight and obesity may impact on mental health and pregnancy outcome of women enrolled. Psycho-educational interventions aimed to improve the management of physical and emotional issues may reduce the risk of PD and complications during pregnancy.

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Section: Introductionmentioning

confidence: 99%

The impact of body mass index on the pregnancy outcomes and risk of perinatal depression: Findings from a multicenter Italian study

et al. 2023

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“…It is recognized that the importance of perinatal nutrition has a great impact on the health of the offspring [ 41 , 42 ].The perinatal period represents a special time in the phase of psychological and physiological development of a woman despite the proven action of neuroplasticity of neurons in brain structures, which increases adaptation to hormonal, cognitive, and emotional changes. All this affects disturbances of the daily rhythm (insomnia), anxiety, and progressive weight gain, resulting in lowered self-esteem and lack of self-acceptance: dysmorphophobia [ 43 , 44 , 45 , 46 ]. These factors may signal the progression of new mental dysfunctions and the intensification and recurrence of psychiatric–psychological comorbidities (bipolar, anxiety, depressive disorders).…”

Section: Discussionmentioning

confidence: 99%

Perception of the Body Image in Women after Childbirth and the Specific Determinants of Their Eating Behavior: Cross-Sectional Study (Silesia, Poland)

Grajek

Krupa‐Kotara

Grot

et al. 2022

IJERPH

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Background: Episodes of loss of control over eating during pregnancy affect up to 36% of women during this period. Many women experience natural concerns about weight gain and body-shape changes during pregnancy and the postpartum period, and food cravings and fluctuations in eating patterns during these periods are physiological phenomena. However, pregnancy and the postpartum period may be an additional determinant of eating disorders. Women who perceive their own bodies as significantly deviating from the presented ideal are more likely to experience anxiety/anxiety related to it and also tend to exhibit abnormal eating behaviors. The perception of one’s body figure also plays an important role in maintaining psychological balance Aim: The aim of this study was to assess the perception of body image by postpartum women. The essence of the study was to see if there were psychomarkers associated with lack of control over eating, food restriction, and emotionally motivated eating in the study population. Material and methods: The study was conducted during the fall and winter of 2021. A total of 288 women participated in the study. The age of the subjects ranged from 21 to 45 years. Results: It was found that 198 women (68.8%) were dissatisfied with their current body weight and figure. Respondents with higher post-pregnancy body mass index showed dissatisfaction with their body shape (49.8%; H = 13.042; p = 0.001). Both body satisfaction and BMI level were significant components of the occurrence of pathological phenomena associated with the TFEQ-13 subscales (p < 0.05). Conclusions: Excessive focus on food restriction as well as lack of control over eating had some association with negative self-perception of body image, mainly in the form of body weight dissatisfaction. Eating behaviors showed an association with BMI level and weight satisfaction after pregnancy.

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“…Thus, it is plausible that lower diet intake combined with an inadequate microbiota-gut-brain axis due to elevated levels of anxiety and that lower levels of Self-Efficacy may lead to lower levels B. uniformis . Whether B. uniformis could be a helpful probiotic supporting immune balance and Self-Efficacy in pregnancy through tryptophan levels and fiber in the diet 89 and whether the mediation and balancing effect of B. uniformis between CCLX11 and Self-Efficacy will need to further investigate to determine causality.…”

Section: Discussionmentioning

confidence: 99%

Interactions between Perceived Stress and Microbial-Host Immune Components in Pregnancy

Bernabé

Maki

Cunningham

et al. 2022

Preprint

Self Cite

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BackgroundHigher stress during pregnancy associates with negative outcomes and elevated inflammation. The gut microbiota reflects the environment, lifestyle, and the perinatal period. The gut microbiota, alongside host immune responses, has the potential to aid in identifying when stress is excessive.MethodsTwo U.S. cohorts, of 84 pregnant individuals, composed of urban women of color and suburban white women, completed the Perceived Stress Scale-10 (PSS-10) and provided fecal and blood samples at two time points. Confirmatory Factor Analysis assessed the robustness of a two-factor PSS-10 (Emotional Distress and Self-Efficacy) in the two cohorts. Gut microbiota composition was measured by 16S rRNA amplicon sequencing and the immune system activity was assessed with a panel of 21 T-cell related cytokines and chemokines.ResultsEmotional Distress levels were higher in the suburban compared to the urban cohort, but levels of Self-Efficacy were similar. Emotional Distress and Self-Efficacy levels were associated with distinct taxonomical signatures and the gut microbiota data improved the prediction of Self-Efficacy levels compared with models based on socio-demographic characteristics alone. Integration of self-reported symptoms, microbial and immune information revealed a possible mediation effect of Bacteroides uniformis between the immune system (through CXCL11) and Self-Efficacy.ConclusionsThe study identified links between distinct taxonomical and immunological signatures with perceived stress. The data is congruent with a model where gut microbiome and immune factors may modulate neural plasticity resulting in increased Self-Efficacy during pregnancy. The predictive value of these peripheral markers merit further study.

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Improving Mental Health for the Mother-Infant Dyad by Nutrition and the Maternal Gut Microbiome

Cited by 12 publications

References 88 publications

The impact of body mass index on the pregnancy outcomes and risk of perinatal depression: Findings from a multicenter Italian study

The impact of body mass index on the pregnancy outcomes and risk of perinatal depression: Findings from a multicenter Italian study

Perception of the Body Image in Women after Childbirth and the Specific Determinants of Their Eating Behavior: Cross-Sectional Study (Silesia, Poland)

Interactions between Perceived Stress and Microbial-Host Immune Components in Pregnancy

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