Building Information Modeling (BIM) has unique features that improve safety management in construction by visually identifying potential risks. Integrating BIM with a real-time game engine is a cutting-edge idea for more effective safety management. This study aims to conduct two case studies by integrating BIM data with game engines from two aspects: 1) Construction Safety Training and 2) Pre-construction Safety Management. A framework that covers techniques for extraction of safety ideas, managing the game engine, and character modeling tools and resources is used to carry out the case studies. In the first case study, a construction site was created by Revit, and a real-life scaffolding failure accident was simulated by Unity to warn workers to prevent similar future events. The second case study was conducted on the procedure of evacuation modeling in an emergency, integrating a BIM model and Unity following distinct pathways. This evacuation modeling can be used as a training platform for the occupants to acquaint themselves with the inside facility, show directions of the shortest evacuation path from specific points, and provide necessary information on emergency equipment. Finally, the study explains how the integration of the BIM model and game engine applications can be applied for effective, straightforward, and helpful safety management with the most efficient BIM data transition.