Patients seen in adult and urban pediatric emergency departments have high rates of sexually transmitted infections (STIs). 1-3 Treatment of adolescent patients testing positive for an STI once discharged from the pediatric emergency department is a concern, particularly among those who are asymptomatic and may not understand the importance of treatment. Studies have shown that health care professionals are able to contact patients with their test results; however, it is unclear in the literature whether asymptomatic adolescent Chlamydia trachomatis (CT)-positive patients obtain their prescriptions from pharmacies or Neisseria gonorrhea (GC)-positive patients return for oral and intramuscular treatment. 4,5 The objective of this study was to evaluate treatment compliance among asymptomatic adolescents with positive STI results.