Background: A patient's adherence to an appropriate treatment regimen is necessary to minimize morbidity and mortality associated with childhood asthma. Many factors influence the success of treatment adherence.Objective: The goal of this article was to examine the effect of the mode of medication delivery on the success of treatment adherence in children with asthma.Methods: Relevant clinical studies were identified through a MEDLINE search of articles published from 1966 to 2002, using the search terms adherence, aerosol, asthma, children, compliance, dry powder inhaler, metered-dose inhaler, nebulizer, and pediatric.Results: A relationship seems to exist between treatment adherence and the type of medication delivery system used in childhood asthma. The highest rates of adherence appear to be associated with oral medications.Conclusions: Clinicians should consider the mode of medication delivery as 1 factor that can influence the success of treatment adherence. (Curr Ther Res Clin Exp. 2003;64:34-44)