This article synthesizes advancements in strategies and interventions for decreasing job burnout, with an emphasis on evaluating their effectiveness, implementation challenges, and practical implications across different workplace settings. A comprehensive literature search was conducted across multiple databases, including PubMed, PsycINFO, Scopus, and Web of Science, focusing on articles published from January 2010 to December 2023. Studies were selected based on their empirical evidence regarding interventions aimed at mitigating job burnout. The review adopts a thematic synthesis approach, categorizing interventions into individual-level, organizational strategies, technology-based interventions, and policy-driven approaches. The review highlights a diverse range of effective strategies for combating job burnout. Individual-level interventions, such as mindfulness and stress management training, show promise in enhancing personal resilience and coping mechanisms. Organizational strategies, including workload adjustments and fostering supportive work environments, are crucial in creating a conducive atmosphere for employee well-being. Technology-based interventions, like digital health tools and AI for workload management, offer innovative solutions for real-time stress monitoring and workload optimization. Policy-driven approaches emphasize the importance of legislative changes and industry standards in safeguarding employee well-being. Challenges in implementation and evaluation of interventions, including methodological limitations and the need for longitudinal studies, are discussed. Addressing job burnout requires a multi-faceted approach, integrating individual, organizational, technological, and policy-level interventions. Future efforts should focus on the development and rigorous evaluation of comprehensive strategies that are scalable, accessible, and tailored to the evolving nature of work. Collaborative efforts among stakeholders are essential in creating sustainable solutions for mitigating job burnout.