Improving quality and efficiency of translational research: Environmental scan of adaptive capacity and preparedness of Clinical and Translational Science Award Program hubs

Shah, Raj C.; Hoyo, Verónica; Moussatche, Patricia; Volkov, Boris B.

doi:10.1017/cts.2022.423

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…These data confirm earlier institutional and CTSA-wide surveys and are not surprising, given the widespread mandated restrictions on non-COVID-related clinical research early in the pandemic [2][3][4][6][7][8]. Additional common reasons for decreased activity reported in this and previous surveys include concerns for the safety of research participants, investigators, and staff, and staffing shortages.…”

Section: Discussionsupporting

confidence: 86%

“…A number of publications from CTSA sites have outlined lessons learned from the COVID-19 pandemic and proposals to prepare the clinical research enterprise for future public health emergencies [1][2][3][4]6,15]. Our survey results underscore many of these findings, highlighting the value of a robust patient-oriented clinical research infrastructure that can rapidly respond to evolving events by reducing nonessential research activities, pivoting to innovative methods that allow clinical research to proceed in a virtual environment, and deploying CRCs' considerable resources to support pandemic-related research [16].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, sharing lessons learned and plans for future readiness across the CTSA network of CRCs can be invaluable for avoiding pitfalls and highlighting successful operations during a time of unprecedented challenges. Previous CTSA publications have recommended that institutions complete readiness evaluations and put in place workflows, training, and liaison services that can be rapidly deployed for future public health emergencies [4,6,7,15,17]. Supplementary material.…”

Section: Discussionmentioning

confidence: 99%

“…Previous CTSA-wide surveys of CRCs were conducted in 2020, during the first year of the pandemic, when less was understood regarding COVID-19 transmission, personal protective equipment was limited, and COVID-19 vaccines had not yet been developed [ 1 – 4 , 6 , 7 ]. Our survey is the first one that covers the second year of the pandemic, adding valuable insights to how CRCs started to recover from initial severe constraints on activities.…”

Section: Discussionmentioning

confidence: 99%

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Impact of the COVID-19 pandemic on CTSA Clinical Research Centers over 2 years

Samuels,

Hommeyer,

Booty

et al. 2023

J. Clin. Trans. Sci.

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Introduction:The COVID-19 pandemic had an abrupt impact on patient-oriented research early in the pandemic. CTSA Clinical Research Centers (CRCs) rapidly adapted to this challenge, but the continued impact of later phases of the pandemic on CRC operations is not clear. Methods: An online REDCap survey of CTSA CRCs was developed that covered the first 2 years of the pandemic. The survey focused on impact on CRC functions, mitigation strategies, recovery of CRC activities, CRC contributions to COVID-related research, and potential lessons for future public health emergencies. The survey was sent to CRC directors at 61 CTSA Hubs in May 2022. Results: Twenty-seven Hubs (44%) responded to the survey. Most CRCs reported greater than 50% declines in inpatient census in the first year of the pandemic, with less severe impacts on outpatient census. CRCs pivoted to support COVID-related research and adopted innovative technology-driven approaches to support clinical research. Census improved in the second year of the pandemic in most CRCs but often remained below prepandemic levels, and greater than half of CRCs reported decreased revenue. Conclusions: CTSA-supported CRCs faced unprecedented challenges at the onset of the COVID-19 pandemic and responded rapidly to support COVID-related research and implement innovative approaches that allowed patient-oriented research activities to resume. However, many CRCs continued to report decreased research activities in the second year of the pandemic, and the long-term effects on CRC operations on finances are not clear. CRCs will likely need to evolve to provide support in nontraditional ways.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of the COVID-19 pandemic on CTSA Clinical Research Centers over 2 years

Samuels,

Hommeyer,

Booty

et al. 2023

J. Clin. Trans. Sci.

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“…This percentage was consistent across all sizes and age categories. This was an important number given the impact of the COVID-19 pandemic and the shutdown of activities and another testimonial published concerning the adaptive capacity of the group [12][13][14][15][16][17][18][19].…”

Section: Evaluation Team Characteristicsmentioning

confidence: 99%

A landscape assessment of CTSA evaluators and their work in the CTSA consortium, 2021 survey findings

Hoyo,

Nehl,

Dozier

et al. 2024

J. Clin. Trans. Sci.

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This article presents a landscape assessment of the findings from the 2021 Clinical and Translational Science Award (CTSA) Evaluators Survey. This survey was the most recent iteration of a well established, national, peer-led systematic snapshot of the CTSA evaluators, their skillsets, listed evaluation resources, preferred methods, and identified best practices. Three questions guided our study: who are the CTSA evaluators, what competencies do they share and how is their work used within hubs. We describe our survey process (logistics of development, deployment, and differences in historical context with prior instruments); and present its main findings. We provide specific recommendations for evaluation practice in two main categories (National vs Group-level) including, among others, the need for a national, strategic plan for evaluation as well as enhanced mentoring and training of the next generation of evaluators. Although based on the challenges and opportunities currently within the CTSA Consortium, takeaways from this study constitute important lessons with potential for application in other large evaluation consortia. To our knowledge, this is the first time 2021 survey findings are disseminated widely, to increase transparency of the CTSA evaluators' work and to motivate conversations within hub and beyond, as to how best to leverage existent evaluative capacity.

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