Improving Quality of Life in Patients with Pituitary Tumours

Crespo, Iris; Santos, Alicia; Resmini, Eugenia; Valassi, Elena; Martínez-Momblán, Ma Antonia; Webb, Susan M.

doi:10.17925/use.2014.10.01.79

Cited by 5 publications

(6 citation statements)

References 37 publications

(57 reference statements)

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“…the cardiovascular system, the musculoskeletal organs, the respiratory system, and the endocrine/metabolic system (4,5,6), as well as an increased mortality, mainly from cardiovascular diseases (5,6,7,8). Acromegaly and its associated comorbidities are associated with reduced quality of life (9,10,11,12). Increased GH secretion leads to increased serum insulin-like growth factor I (IGF1) concentration, insulin resistance, growth of skin, connective tissue, cartilage, bone, organs, and other tissues in the body.…”

Section: Introductionmentioning

confidence: 99%

Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study

Lesén

Granfeldt

Houchard

et al. 2017

European Journal of Endocrinology

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Section: Introductionmentioning

confidence: 99%

Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study

Lesén

Granfeldt

Houchard

et al. 2017

European Journal of Endocrinology

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“…Owing to this delay severe irreversible damage such as changes in joint, soft tissues, voice, and physical appearance have already occurred by the time of diagnosis. Hence treatment, at best, can only slow down the progression of these changes, as the damage has already taken place [31].…”

Section: Discussionmentioning

confidence: 99%

Surgically treated acromegaly patients have a similar quality of life whether controlled by surgery or requiring additional medical therapy (QuaLAT Study)

et al. 2021

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Purpose There is no consensus on quality of life (QOL) in patients with acromegaly requiring medical treatment after surgery compared with those achieving remission by surgery alone. Methods QuaLAT is a cross-sectional study comparing QOL in surgery-only treated acromegaly patients versus those requiring medical treatment post-surgery. Patients attending clinics were identified and divided into—Group 1: patients who had surgery only and were in biochemical remission, Group 2: all patients on medical treatment post-surgery, Group 3: patients from Group 2 with biochemical control. Participants were asked to fill three questionnaires; Acromegaly Quality of Life Questionnaire (ACROQOL), 36-Item Short Form Survey (SF36), and Fatigue Severity Scale (FSS). Results There were 32 patients in Group 1 and 25 in Group 2. There was no difference in QOL scores between groups 1 and 2, as measured by ACROQOL (mean difference [MD] = − 2.5, 95% CI − 16.6 to 11.6; p = 0.72), SF36v2 [Physical component score (PCS) MD = − 4.9, 95% CI − 10.9 to 1.2; p = 0.12; mental component score MD = − 3.0, 95% CI − 10.5 to 4.4; p = 0.44], or FSS (MD = − 0.004, 95% CI − 1.14 to 1.33; p = 0.1). Comparison between groups 1 and 3 however showed that PCS (and 3 subdomains) was significantly better in group 3 (MD = − 8.3, 95% CI − 14.8 to -1.8; p = 0.01). All three QOL scores were lower when compared with healthy controls. Conclusions Medical treatment not only achieves a QOL comparable to surgery, it may also be associated with better QOL in physical subdomains. When compared with healthy controls, QOL remains worse in treated acromegaly patients compared to controls.

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“…1 Benign tumors may also cause headache or visual disturbances due to pressure on surrounding structures. 1 These tumors may frequently necessitate surgical intervention. Moreover, resection of benign skull base tumors may, in itself, be an independent cause of significant side effects and complications and may therefore lead to impaired QOL.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Evaluation of Quality of Life in Patients Undergoing Extended Endoscopic Endonasal Surgery for Benign Pituitary Gland Lesion

Neiderman

Wengier

Dominsky

et al. 2021

J Neurol Surg B Skull Base

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Introduction Endoscopic endonasal surgery (EES) has become the preferred approach for pituitary tumor resection. Nevertheless, research on quality of life related to pituitary adenoma surgery is scarce. Objective The aim of the study is to evaluate short-term quality of life in patients after endoscopic endonasal resection of pituitary tumors and to find predictors for poor quality of life (QOL) outcome. Materials and Methods A prospective cohort study was conducted, including all patients who underwent EES for pituitary tumors in a tertiary medical referral center. Recruited patients completed the Anterior Skull Base Disease-Specific QOL (ASBS-Q) questionnaire and the Sinonasal Outcome Test 22 (SNOT-22) questionnaire before surgery, 2 and 4 to 6 months after surgery. Demographic and clinical data was collected. Results Our study included 49 patients. The overall ASBS-Q scores significantly improved 4 to 6 months after surgery (4.46 vs. 4.2, p < 0.05). We found a significant improvement in QOL related to emotional state 2 months post surgery (4.41 vs. 3.87, p < 0.05), which became borderline significant 4 to 6 months post surgery. There was a significant improvement in pain (4.5 vs. 4.08, p < 0.05) and vitality (4.43 vs. 4.16, p < 0.05) domains 4 to 6 months post surgery. SNOT-22 scores did not change significantly postoperatively. Factors such as secreting and non-secreting tumors, tumor size, intraoperative cerebrospinal fluid leak, gross tumor resection, endocrine remission, and the use of nasoseptal flap reconstruction did not have a significant effect on QOL. Conclusion We found that patients after EES reported improved QOL 4 to 6 months post surgery. Specific improvement was noted in the QOL related to pain and vitality.

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Improving Quality of Life in Patients with Pituitary Tumours

Cited by 5 publications

References 37 publications

Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study

Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study

Surgically treated acromegaly patients have a similar quality of life whether controlled by surgery or requiring additional medical therapy (QuaLAT Study)

A Prospective Evaluation of Quality of Life in Patients Undergoing Extended Endoscopic Endonasal Surgery for Benign Pituitary Gland Lesion

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