Quality of life (QoL) after deceased donor liver transplantation is increasingly recognized as a major outcome parameter. We reviewed recent publications in this rapidly evolving field in order to summarize recent achievements in the field and to define opportunities and perspectives for research and improvement of patient care. QoL does improve after liver transplantation according to a typical pattern. During the first year, there is a significant improvement in QoL. After one year, the improvement does stabilise and tends to decline slightly. In addition to the physical condition, different psychological parameters (such as depression, anxiety, sexual function) and sociodemographic elements (professional state, sex, marital state) seem to impact QoL. Opportunities for further research are the use of dedicated questionnaires and identification of influencing factors for QoL. Core tip: Quality of life (QoL) after deceased donor liver transplantation (LT) is increasingly recognized as a major outcome parameter. This review summarizes a broad spectrum of factors that influence QoL in LT and elucidates the evolution in time of physical and mental QoL after LT. Furthermore attention is given to areas for further investigation and the use of self-report QoL questionnaires in LT. This way, we want to offer a recent and complete overview in this rapidly evolving field.