Clinical research and medical education regarding dermatoses in people with skin of color (SoC) have historically been neglected, which has played a role in physicians lacking confidence and competence in recognizing and managing dermatoses in diverse cohorts. This has contributed to poorer outcomes in people with SoC in objective domains, such as disease severity indices and prognoses, and subjective domains, such as patient-reported quality-of-life indices. In the first instance, physicians should understand the basic physiological differences underpinning SoC diversity and its clinical implications. This narrative review provides an introductory evidence-based discussion on clinically important topics relating to SoC aimed at non-dermatologists. Topics covered include the cellular basis underpinning skin color diversity and how this affects photodermatoses and malignancies, as well as an overview of how scarring and inflammatory conditions may present differently in people with SoC.