Improving Sperm Viability After Spinal Cord Injury Using Hyperbaric Therapy

Falavigna, Asdrúbal; Silva, Pedro Giovâni da; Conzatti, Lucas Piccoli; Corbellini, L.; Cagliari, Caroline Sbardellotto; Pasqualotto, Fábio Firmbach

doi:10.1016/j.wneu.2018.01.216

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Some studies in animal models have shown that HBO can reduce testicular injury under hypoxic conditions, such as varicocele testis or spinal cord injury . It is speculated that hypoxic stress induces overexpression of antiapoptotic proteins, such as Bcl‐2, and downregulation of caspase‐9 in the internal spermatic vein .…”

Section: Male Infertilitymentioning

confidence: 99%

Potential of hyperbaric oxygen in urological diseases

et al. 2019

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Abbreviations & Acronyms AKI = acute kidney injury Alum = aluminium potassium sulfate ATA = atmosphere absolute CR = complete response CRPC = castration-resistant prostate cancer DC = dystrophic calcification EMT = epithelial-tomesenchymal transition FG = Fournier gangrene FGSI = Fournier Gangrene Severity Index HA = hyaluronic acid HBO = hyperbaric oxygen HIC = Hunner type interstitial cystitis IC/PBS = interstitial cystitis/painful bladder syndrome NHIC = non-Hunner type interstitial cystitis PR = partial response RHC = radiation-induced hemorrhagic cystitis ROS = reactive oxygen species RT = radiation therapy TRP = transient receptor potential channel WF10 = immunokine Correspondence: TomoakiAbstract: Hyperbaric oxygen therapy is a promising medical technology that delivers oxygen to targeted tissues at high pressure to increase the amount of dissolved oxygen in the blood. Over the past three decades, hyperbaric oxygen has been used in a variety of conditions, including radiation-induced tissue injuries, non-healing states with ischemia and malignant neoplasms. In the field of urology, hyperbaric oxygen has also been applied to some pathological conditions (e.g. radiation-induced hemorrhagic cystitis, Fournier gangrene, interstitial cystitis, male infertility, acute kidney injury and urological cancers). In normal and injured tissues, hyperoxia from hyperbaric oxygen therapy contributes to anti-inflammation, angiogenesis through endothelial proliferation, enhanced fibroblastic activity, increased lymphocyte and macrophage activity, and bactericidal effects with the aim of wound repair. In cancerous tissues, the enhanced supply of oxygen into the hypoxic cancer cells can exert inhibitory effects on factors that contribute to their aggressiveness (e.g. cell survival, escape from apoptosis, epithelial-to-mesenchymal transition and tumor immunotolerance), and sensitize the tumor to radiation therapy and chemotherapy. However, further research, including multicenter clinical studies, is essential for determining the role of hyperbaric oxygen therapy in refractory urological diseases that are resistant to conventional therapies.

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Section: Male Infertilitymentioning

confidence: 99%