Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis (<scp>IOTA</scp>) studies

Kaijser, Jeroen; Bourne, Tom; Valentin, Lil; Sayasneh, Ahmad; Holsbeke, C. Van; Vergote, Ignace; Testa, Antonia Carla; Franchi, D.; Calster, Ben Van; Timmerman, Dirk

doi:10.1002/uog.12323

Cited by 184 publications

(169 citation statements)

References 64 publications

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“…5 can be classified using subjective assessment by an experienced ultrasound operator, or given the high prevalence of malignancy in this group they can all be classified as malignant to increase the sensitivity for ovarian cancer. 6 On prospective validation both by the IOTA group (two studies including 1938 and 2403 patients, respectively) 7,8 and by other research teams (nine studies including a total of 2101 tumors) 9-17 , the Simple Rules were applicable in 77 to 94% of tumors (range between studies). The malignancy rate ranged from 1% to 9% in cases classified as benign, from 69% to 94% in cases classified as malignant, and from 13% to 53% in inconclusive cases.…”

Section: Introductionmentioning

confidence: 98%

Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group

Timmerman

Calster

Testa

et al. 2016

American Journal of Obstetrics and Gynecology

260

220

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Section: Introductionmentioning

confidence: 98%

Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group

Timmerman

Calster

Testa

et al. 2016

American Journal of Obstetrics and Gynecology

260

220

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“…The local or systemic administra- To evaluate peri-trophoblastic vascularization, we applied the same score system that the International Ovarian Tumor Analysis study used to describe the amount of blood flow within the solid components of an ovarian mass [6]. A score of 1 was given when no blood flow was found, a score of 2 was given when only minimal flow could be detected, a score of 3 was given when a rather strong flow was detected, and a score of 4 was given when peri-trophoblastic vascularization was profuse.…”

Section: Introductionmentioning

confidence: 99%

Combined Systemic and Hysteroscopic Intra-Amniotic Injection of Methotrexate Associated with Hysteroscopic Resection for Cervical Pregnancy: A Cutting-Edge Approach for an Uncommon Condition

et al. 2017

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This case report of a 36-year-old woman with a diagnosis of cervical pregnancy describes a novel approach to this rare form of ectopic pregnancy, which was successfully treated with systemic and local methotrexate (MTX) therapy combined with hysteroscopic resection. After local and systemic administration of MTX, the patient underwent hysteroscopic resection of the cervical pregnancy using a 27 bipolar resectoscope with a 4-mm loop. The cervical pregnancy was completely treated, and satisfactory hemostasis was achieved with electrocoagulation. The reported case and literature review demonstrate that the combination of systemic and local (hysteroscopic) administration of MTX with hysteroscopic resection could offer the possibility of a safe, successful, minimally invasive, and fertility-sparing surgical treatment for cervical pregnancy.

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“…Swollen left iliac lymph nodes were recognized but without clinical significance. Based on the above reported ultrasonographic data and regarding IOTA simple rules [7,8], the ovarian lesion was characterized as a "probably malignant tumor" (Figure 1). …”

Section: Case Presentationmentioning

confidence: 99%

Immature Ovarian Teratoma in a 21 Year –Old Woman: A Case Report and Review of the Literature.

Stavrou¹

2015

J Gen Pract

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with specific tumor markers .So, tumor markers Ca 15-3, Ca19-9, Ca 125, and CEA were fluctuated in normal ranges. Serum levels of alphafetoprotein (a-FP) were significantly elevated reaching the plateau of 392 iu/ ml (normal ranges: <9.5 iu/ml), supporting the sonographically evoked opinion of underlying malignancy. Except that AST (62 IU/L), ALT (73 IU/L) and LDH (309 IU/L) were mildly increased.Because of the young profile of the patient, MRI of upper and lower abdomen has been also performed; similarly to ultrasonographic report, MRI noticed the presence of excessive ascites; it also described a heterogeneous right ovarian mass of 88 × 81 × 100 mm presenting cystic, solid and hemorrhagic contents, fixed to the broad ligament of the uterus. It also revealed 2 thin walled cysts of 4, 3 cm and 2, 4 cm in the left ovary without solid parts. Intraperitoneal tissue in the region of upper abdomen was described, implying the possibility of underlying peritoneal carcinomatosis. The liver, the biliary system, the spleen, the pancreas and the adrenals were normal. MRI didn't reveal enlarged paraaortic, mesenteric, iliac or inguinal lymph nodes (Figure 2). Chest X-ray and ultrasonographically breast examination were normal. Initially, ascites suction was realized in order to alleviate from pressing symptoms. In the operation theater under general anesthesia, laparoscopy was performed with the technique of the four ports for better abdominal exploration in the overweight patient; 4 to 5 liters of ascites were aspirated for cytological examination. The organs of the upper abdomen were normal, without implantations in the peritoneum or omental disease. The uterus and the left adnexa were normal but a mass 10-12 cm of right ovary characterized by abnormal surface was revealed. So exploratory laparotomy followed with vertical incision .Then the cystic lesion was removed and sent for frozen section. The rapid biopsy was positive for

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Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis (IOTA) studies

Abstract: ABSTRACT

Cited by 184 publications

References 64 publications

Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group

Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group

Combined Systemic and Hysteroscopic Intra-Amniotic Injection of Methotrexate Associated with Hysteroscopic Resection for Cervical Pregnancy: A Cutting-Edge Approach for an Uncommon Condition

Immature Ovarian Teratoma in a 21 Year –Old Woman: A Case Report and Review of the Literature.

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