Vortex generators (VGs) attached to the leading edge of an agricultural aircraft are purported to control airflow over the upper surface of the wing by creating small vortices that delay boundary layer separation, thereby improving the performance of the aircraft. These devices are commercially available for use in the aviation industry, primarily to increase pilot control of the aircraft. The benefits attributed to VGs remain largely descriptive and anecdotal in nature without rigorous empirical assessment in the field. The intent of this study was to evaluate whether this aerodynamic device could improve deposition or reduce drift when mounted on an agricultural aircraft. Airborne drift and ground deposition were measured with monofilament lines and Mylar cards, respectively. Deposits were expressed as percent of fluorometric response using a spectrofluorophotometer. There were 46% fewer downwind drift deposits on monofilament lines when VGs were installed than when VGs were not installed. Whether or not VGs were installed on the aircraft was the predominant factor which influenced deposition on monofilament lines. Spray deposits on Mylar cards placed at ground level downwind of the applications at three different locations (5, 10, and 20 m) varied significantly (p < 0.0001) between treatments, with corresponding 31, 54, and 61% reductions in downwind deposits when VGs were installed. While these findings overall are positive, this is the first known study of its type, and more research is warranted to better understand the role of vortex generators in the reduction in drift relative to aerially applied sprays.