Improving the Antibacterial Activity of Curcumin Loaded Nanoparticles in Wastewater Treatment by Enhancing Permeability and Sustained Release

Shajari, Mozhgan; Zamani, Mostafa; Ahmadi, Nahid; Rostamizadeh, Kobra; Shapouri, Reza

doi:10.1007/s10924-021-02338-5

Cited by 10 publications

(3 citation statements)

References 34 publications

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“…How to cite this article: Shajari, M., Ahmadi, N., Zamani, M., Rostamizadeh, K., & Shapouri, R. (2022). Hospital wastewater treatment using eco-friendly eugenol nanostructured lipid carriers: Formulation, optimization, and in vitro study for antibacterial and antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, investigation of the phenomenon of drug resistance is essential. Recently, plant‐based drugs have shown that they can reduce the resistance of bacteria against chemical drugs utilizing nanotechnology (Liu et al, 2017; Shajari et al, 2022; Xiaolei et al, 2013). Nowadays, the highly desirable properties of nanoparticles have made them great candidates to be used for delivering cargos in vitro and in vivo (Aghajanzadeh et al, 2019; Ayubi et al, 2019; Zamani et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Hospital wastewater treatment using eco‐friendly eugenol nanostructured lipid carriers: Formulation, optimization, and in vitro study for antibacterial and antioxidant properties

Shajari

Ahmadi

Zamani

et al. 2022

Water Environment Research

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In this study, nano‐formulation has been used to tackle one of the most important environmental problems which can be considered a major threat to human health. We prepared some eco‐friendly nanostructured lipid carriers (NLCs) as delivery agents to properly deliver an antibacterial agent (eugenol) into hospital wastewater in order to control bacterial growth. Eugenol‐loaded nanostructured lipid carriers were prepared by hot high‐speed homogenization. Then, the prepared nanocarriers were characterized using different techniques such as transmission electron microscopy, Fourier transform infrared, and dynamic scanning calorimetry. The turbidity assay and colony counting method were used to determine the ability of the prepared eugenol‐loaded nanostructured lipid carriers to inhibit bacterial growth rate in the culture media and hospital wastewater, respectively. The mean size and zeta potential of NLC‐eugenol were 78.12 ± 6.1 nm and −29.43 ± 2.21 mV, respectively. The results showed that the highest inhibitory effect of NLC‐eugenol in culture media was seen in standard and wild Staphylococcus aureus strains (43.42% and 26.41%, respectively) with a concentration of 0.125 μM. The antibacterial activity of NLC‐eugenol in sterile wastewater on wild strains of bacteria showed that the most effective concentration to reduce bacterial amounts was 0.125 μM on wild S. aureus and Enterococcus faecalis strains (38% and 33.47%, respectively) at 37°C. The NLC‐eugenol with a concentration of 0.125 μM showed the greatest effect of reducing total microbial agents by 28.66% in hospital wastewater at 25°C. The highest antibacterial effect achieved using the 0.125 μM concentration is due to the egel phenomenon. Also, the mechanism of action of NLC‐eugenol is cell wall destruction and eventually cell death. The results showed that NLC‐eugenol with a concentration of 0.125 μM can reduce wild bacterial strains in sterilized wastewater and hospital wastewater, which can prove the great potential of the prepared eugenol‐loaded nanostructured lipid carriers to control bacterial growth. Practitioner Points NLC is one of the safest biodegradable and environmentally friendly carriers, which is nontoxic for humans and the environment. Eugenol is a natural compound, which makes it less toxic for the environment while being toxic for bacteria. Therefore, our method has the least side effect in comparison with existing methods for wastewater treatment. The gradual release of eugenol from NLC nanoparticles can effectively control the pathogenic factors of wastewater.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hospital wastewater treatment using eco‐friendly eugenol nanostructured lipid carriers: Formulation, optimization, and in vitro study for antibacterial and antioxidant properties

Shajari

Ahmadi

Zamani

et al. 2022

Water Environment Research

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“…27 MPEG and Sn(Oct) 2 were dissolved in 100 mL of toluene under magnetic stirring. Then, ε-CL was slowly added to the mixture and reacted in a nitrogen atmosphere at 120 C for 24 h. 28 After that, dichloromethane was added to the crude product and residual toluene was rotary evaporated. Then, cold ether was added to the crude product, and the precipitate was collected and washed three times with cold ether.…”

Section: Synthesis and Characterization Of Mpeg-co-pclmentioning

confidence: 99%

Effects of methoxy polyethylene glycol‐polycaprolactone block copolymers and silica nanoparticles on the mechanical, tissue affinity and antibacterial properties of n‐butyl cyanoacrylate adhesive

Jin²,

2023

J of Applied Polymer Sci

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Cyanoacrylates are widely used as surgical tissue adhesives because of their high biodegradability, but they are brittle and have poor tissue affinity. In this study, methoxy polyethylene glycol‐polycaprolactone block copolymers (MPEG‐co‐PCLs) with different PCL chain lengths were synthesized by ring‐opening polymerization. Then, a new tissue adhesive with excellent mechanical properties, tissue affinity, antibacterial properties, and coagulation performances was prepared by incorporating MPEG‐co‐PCL and silica nanoparticles (SNPs) into n‐butyl cyanoacrylate (BCA). The optimal MPEG: PCL ratio is 1:4 (MP‐3), and the optimal mass ratio of MPEG‐co‐PCL and SNPs (0.5SNPs/0.5MP‐3) is 0.5 wt.%. Compared to BCA, the adhesion strength and flexibility of 0.5SNPs/0.5MP‐3 are dramatically improved by 110% and 244%, respectively. MPEG‐co‐PCL can fully exploit the advantages of homopolymers, and therefore, improve the tissue affinity and adhesion strength of the adhesive and avoid BCA polymerization initiated by MPEG and poor compatibility of PCL with BCA. SNPs can also compensate for the lack of antibacterial properties of BCA against Gram‐negative bacteria. The E. coli inhibition circle of 0.5SNPs/0.5MP‐3 is twice as large as BCA. SNPs can also improve coagulation by promoting platelet aggregation. This work provides an effective strategy for developing adhesives with potential clinical applications.

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Polyphenols for Wastewater and Industrial Influents’ Treatment

Salman,

Farooq,

Rahman

et al. 2024

Science and Engineering of Polyphenols

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Improving the Antibacterial Activity of Curcumin Loaded Nanoparticles in Wastewater Treatment by Enhancing Permeability and Sustained Release

Cited by 10 publications

References 34 publications

Hospital wastewater treatment using eco‐friendly eugenol nanostructured lipid carriers: Formulation, optimization, and in vitro study for antibacterial and antioxidant properties

Hospital wastewater treatment using eco‐friendly eugenol nanostructured lipid carriers: Formulation, optimization, and in vitro study for antibacterial and antioxidant properties

Effects of methoxy polyethylene glycol‐polycaprolactone block copolymers and silica nanoparticles on the mechanical, tissue affinity and antibacterial properties of n‐butyl cyanoacrylate adhesive

Polyphenols for Wastewater and Industrial Influents’ Treatment

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