Improving the Antimicrobial Power of Low‐Effective Antimicrobial Molecules Through Nanotechnology

Ruiz-Rico, María; Pérez‐Esteve, Édgar; Torre, Cristina de la; Jiménez-Belenguer, Ana; Quiles, Amparo; Marcos, M. Dolores; Martínez‐Máñez, Ramón; Baviera, José Manuel Barat

doi:10.1111/1750-3841.14211

Cited by 20 publications

(16 citation statements)

References 35 publications

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“…These studies demonstrated that the combination of the cell wall disruption capability of G3 dendrimer and the antibiotic effect of LVX into a unique MSNs-based nanosystem has a synergistic antimicrobial effect. Comparable results have been found for Gram-positive Listeria monocytogene by using polyamine-functionalized MSNs, as reported by Barat and co-workers [ 61 ]. The attractive forces between positive amine corona on MSNs and negative charges in bacteria membrane prompt cell membrane disruption.…”

Section: Targeted Delivery Of Antimicrobialssupporting

confidence: 75%

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Colilla

Vallet‐Regí

2020

IJMS

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The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.

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Section: Targeted Delivery Of Antimicrobialssupporting

confidence: 75%

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Colilla

Vallet‐Regí

2020

IJMS

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“…In general, the colour of the H. pylori cells remained green at the 0 h incubation time, which meant that cells were viable and membranes remained intact. In contrast, after 24 h of incubation with the EOCfunctionalised particles, the absence of cells or the presence of red-coloured cells indicated a damaged cell envelope, and eventual bacterial death (Ruiz-Rico et al 2018).…”

Section: Materials Characterisationmentioning

confidence: 90%

“…surface will confer antimicrobial properties to widely applied materials by creating antimicrobial functionalised materials. Previous studies have demonstrated that the immobilisation process allows the antimicrobial power of the attached molecules to anchor, concentrate and improve (Li and Wang 2013;Ruiz-Rico et al 2018), and can also prevent the limitations of free molecules.…”

Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial activity of immobilised essential oil components against Helicobacter pylori

Ruiz-Rico

Moreno

Baviera

2019

World J Microbiol Biotechnol

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Available disinfection methods and therapies against Helicobacter pylori have multiple disadvantages, such as increased prevalence of antibiotic-resistant strains, which requires the search for novel effective antimicrobial agents against H. pylori. Among them, naturallyoccurring antimicrobial compounds, like essential oil components, have been reported as substances with anti-H. pylori potential. To avoid the disadvantages associated with using essential oil components in their free form, including volatility, low water solubility and intense sensory properties, their immobilisation in inert supports has recently been developed. This study sought to evaluate the inhibitory properties of essential oil components immobilised on silica microparticles against H. pylori and to elucidate the mechanism of action of the immobilised antimicrobials. After the preparation and characterisation of the antimicrobial supports, the susceptibility of H. pylori in the presence of the immobilised compounds was assessed by plate count, fluorescent viability staining and DVC-FISH analyses. The antimicrobial supports were found to inhibit H. pylori growth, and to induce morphological and metabolic alterations to the H. pylori membrane, with a minimum bactericidal concentration (MBC) value between 25-50 μg/ml according to the tested EOC. These findings indicate that immobilised essential oil components can be used as potential antimicrobial agents for H. pylori clearance and treatment.

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“…A similar study against L. monocytogenes G + was carried out by J. M. Barat et al [92]. Equivalent results were obtained when studying the effect of anchoring polyamines on the surface of MSNPs.…”

Section: Effect On Planktonic Bacteriamentioning

confidence: 77%

Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection

2018

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Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the multiple ways of action in which MSM can be used to fight bacterial infection, including early detection, drug release, targeting bacteria or biofilm, antifouling surfaces, and adjuvant capacity. This review focus mainly on those that act as a drug delivery system, and therefore that have an essential characteristic, which is their great loading capacity. Since MSM have advantages in all stages of combatting bacterial infection; its prevention, detection and finally in its treatment, we can venture to talk about them as the “nightmare of bacteria”.

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Improving the Antimicrobial Power of Low‐Effective Antimicrobial Molecules Through Nanotechnology

Cited by 20 publications

References 35 publications

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

In vitro antimicrobial activity of immobilised essential oil components against Helicobacter pylori

Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection

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