Improving the cytological diagnosis of intraocular lymphoma from vitreous fluid

Ranty, Marie–Laure; Laurent, Césari; Aziza, Jacqueline; Mahieu, L.; Ollé, Priscille; Quintyn, J.–C.; Garnier, L.; Bienvenu, Jacques; Collin, Laetitia; Delisle, Marie–Bernadette; Courtade-Saïdi, Monique

doi:10.1111/his.12621

Cited by 19 publications

(14 citation statements)

References 29 publications

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“…Intraocular lymphomas include primary central nervous system lymphomas involving uvea and metastatic systemic lymphoma [20]. Intraocular lymphomas comprise the vast majority of B-lineage and most diffuse large B cell lymphomas [13,20].…”

Section: Discussionmentioning

confidence: 99%

“…Intraocular lymphomas comprise the vast majority of B-lineage and most diffuse large B cell lymphomas [13,20]. Upon microscopic examination, the lymphoma cells are typically characterized by a size 2-4 times that of normal lymphocytes, nuclear polymorphism with prominent nucleoli and an irregular cell shape [20,30].…”

Section: Discussionmentioning

confidence: 99%

“…When compared with lymphomatous vitreous fluids, hyalitis fluids are more cellular. Repeated vitrectomy and appropriate liquid management can improve the diagnosis rate [8,16,20]. For example, vitreous fluid can be collected in a culture medium to avoid cell lysis.…”

Section: Discussionmentioning

confidence: 99%

“…Vitrectomy can also be used as a diagnostic tool in cases of clinically undiagnosed uveitis or uveitis with an atypical clinical course, suspected infectious endophthalmitis or suspicion of intraocular malignancy [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]. In these cases, cytological analysis combined with appropriate ancillary testing, such as microbiological analysis, flow cytometry and interleukin (IL) measurement, is a valuable tool that can lead to a final clinical diagnosis in most cases [8].…”

Section: Introductionmentioning

confidence: 99%

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Cytopathology of Vitreous Humor Samples in Routine Practice

Boulagnon-Rombi¹,

Ducasse

Patey³

et al. 2016

Acta Cytologica

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Objective: To describe findings in vitreous fluid samples in routine cytology practice. Study Design: The pathology archives from 1988 to 2008 at our institution were searched for vitreous samples. The slides were reviewed and clinical and follow-up information was obtained. Results: One hundred and eighty-two vitreous fluid samples from 166 patients were analyzed. Most of the samples had been collected for vitreous hemorrhage (75 cases). The second reason for vitreous sample cytological evaluation was an intraocular inflammatory process (55 cases). A specific cause of inflammation was found by combining clinical, microbiological and cytopathological findings in 19 cases, i.e. infection in 7, sarcoidosis in 3, retinal necrosis in 3, lens-induced endophthalmitis in 2, uveitis associated with systemic disease in 2, retrobulbar neuritis in 1 and sympathetic ophthalmia in 1. Among the 19 samples from 16 patients collected to rule out malignancy, 8 had a confirmed intraocular malignancy. Malignant cells were observed in 5 cases (3 lymphomas, 1 melanoma and 1 carcinoma). Undiagnosed malignancies included 2 lymphomas and 1 choroidal melanoma. Other samples were collected during surgery for retinal detachment and cataracts. Conclusions: In routine practice,cytology of the vitreous fluid is performed in many and varied situationsthat are most often nonneoplastic.In nonneoplastic cases, cytology is a useful adjunct to vitrectomy, in spite of its limitations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cytopathology of Vitreous Humor Samples in Routine Practice

Boulagnon-Rombi¹,

Ducasse

Patey³

et al. 2016

Acta Cytologica

View full text Add to dashboard Cite

show abstract

“…It was developed in 1966 by Moore and his coworker at Roswell Park Memorial Institute and has been used for the culture of normal and neoplastic leukocytes [2].…”

Section: Introductionmentioning

confidence: 99%